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HRP conjugated Monoclonal Anti-DXD&Exatecan Antibody, Mouse IgG1

COADS MS
DS
  • Antibody Internalization Detection Reagent (IGG-PZF2001) monitors endocytosis in live cells

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Cat. No. / Size
Price
Qty
DXD-PLM684-25ug
$705.00
DXD-PLM684-200ug
$4920.00
ETA of in-stock products:2 business days
Sub-Total$ 0
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Product Details

  • Specificity

    Specifically recognizes the target-DXD&Exatecan.

  • Source

    HRP conjugated Monoclonal Anti-DXD&Exatecan Antibody, Mouse IgG1 is a Mouse monoclonal antibody recombinantly expressed from HEK293 cells.

  • Isotype

    Mouse IgG1 | Mouse kappa

  • Conjugate

    HRP-Conjugated

  • Reactivity

    Chemical

  • Immunogen

    DXD

  • Application

    Application
    Recommended Usage
    ELISA
    2-5000 ng/mL

  • Purification

    Protein A purified / Protein G purified

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please protect from light and avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.

  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • Bioactivity-ELISA

    DXD ELISA

    Immobilized Human Her2, His Tag (Cat. No. HE2-H5225) at 1 μg/mL, add Trastuzumab Deruxtecan in the 100% Human Serum and then add HRP conjugated Monoclonal Anti-DXD&Exatecan Antibody, Mouse IgG1 (Cat. No. DXD-PLM684) at 0.1 μg/mL (QC tested).

    Protocol

  • DXD ELISA

    Immobilized Trastuzumab-Exatcan at 1 μg/mL (100 μL/well) can bind HRP conjugated Mouse Anti-DXD&Exatecan Antibody, Mouse IgG1 (Cat. No. DXD-PLM684) with a linear range of 1-16 ng/mL (Routinely tested).

    Protocol

  • DXD ELISA

    Immobilized ADC-DXD at 1 μg/mL (100 μL/well) can bind HRP conjugated Mouse Anti-DXD&Exatecan Antibody, Mouse IgG1 (Cat. No. DXD-PLM684) with a linear range of 0.5-31 ng/mL (Routinely tested).

    Protocol

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Background

Dxd (Exatecan ADC derivative) is a potent DNA topoisomerase I inhibitor with an IC50 of 0.31 uM for targeting ADCs (DS-8201A). Dxd was cytotoxic to human tumor cell lines KPL-4, NCI-N87 and SK-BR, 3 and the IC50s of MDA-MB-468 was 1.43 NM-4.07 nM, while lgGADC (Dxd as payload) had no inhibitory effect on HER2 expression in the 4 cell lines. DS8201a (Dxd as payload) had a significant inhibitory effect on HER2-positive KPL-4 and NCI cell lines N87 and SK-BRwith IC50 values of 26.8, 25.4 and 6.7 ng/mL, respectively, but had no inhibitory effect on MDA MB-468 (IC50, > 10000 - mL). HRP-anti-DXD-antibody is a conjugation product of HRP and anti-DXD-antibody. It can be used in PK, PD analysis and ELISA.

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