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Biotinylated Rabbit Anti-Eribulin Antibody, Rabbit IgG (1M1G11)

COADS MS
DS
  • Antibody Internalization Detection Reagent (IGG-PZF2001) monitors endocytosis in live cells

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Cat. No. / Size
Price
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ERN-BMY12b-25ug
$470.00
ERN-BMY12b-200ug
$1845.00
ETA of in-stock products:2 business days
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Product Details

  • Specificity

    This product is a specific antibody specifically reacts with Eribulin.

  • Source

    Biotinylated Rabbit Anti-Eribulin Antibody, Rabbit IgG (1M1G11) is a Rabbit monoclonal antibody recombinantly expressed from HEK293 cells.

  • Clone

    1M1G11

  • Isotype

    Rabbit IgG | Rabbit Kappa

  • Conjugate

    Biotin

  • Application

    Application
    Recommended Usage
    ELISA
    0.1-125 ng/mL

  • Purification

    Protein A purified / Protein G purified

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.

  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • Bioactivity-ELISA

    Eribulin ELISA

    Immobilized Human FOLR1, Fc Tag (Cat. No. FO1-H5253) at 1 μg/mL, add Farletuzumab Ecteribulin and then add Biotinylated Rabbit Anti-Eribulin Antibody, Rabbit IgG (1M1G11) (Cat. No. ERN-BMY12b) at 0.05 μg/mL. Detection was performed using HRP-conjugated Streptavidin (Acro, Cat. No. STN-NH913) (QC tested).

    Protocol

  • Eribulin ELISA

    Immobilized Human FOLR1, Fc Tag (Cat. No. FO1-H5253) at 1 μg/mL, add Farletuzumab Ecteribulin in the 100% Human Serum and then add Biotinylated Rabbit Anti-Eribulin Antibody, Rabbit IgG (1M1G11) (Cat. No. ERN-BMY12b) at 0.05 μg/mL (QC tested).

    Protocol

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Background

Eribulin is a synthetic analogue of the macrocyclic polyether halichondrin B, which was originally isolated from the Asian sea sponge Halichondria okadai. Eribulin binds specifically to the β-tubulin subunit on the (+) end of the microtubule and potently inhibits elongation of the formed microtubule, while having little or no effect on microtubule depolymerization. Eribulin's potent antimitotic activity and nonmitotic effects on tumor biology make it an interesting candidate for investigation as a MTA payload for ADCs.

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