Biotinylated Monoclonal Anti-G4S linker Antibody, Rabbit IgG (016), CF (carrier free), premium grade

• Seamless Transition from Preclinical to Clinical: Same cell clone, process, and QC as GMP products.
• Enhanced Production Standards: AOF raw materials, pharma-grade excipients, Grade B+A (ISO 5) environment.
• Comprehensive Quality Control: Additional strict testing for process impurities, sterility, and mycoplasma.
• Cost-Effective Solution: GMP-comparable quality at an economical price for early development.
• Risk Mitigation: Enhanced safety through rigorous impurity control and comprehensive testing.

Biotinylated Monoclonal Anti-G4S linker Antibody, Rabbit IgG (016), CF (carrier free), premium grade is a rabbit monoclonal antibody (labelled by chemically labeling technology) recombinantly expressed from human 293 cells (HEK293), it shows superior performance in various applications such as ELISA assays and flow cytometry assays with higher affinity and better specificity.

It is produced under our rigorous quality control system that incorporates a comprehensive set of tests including sterility and endotoxin tests. Product performance is carefully validated and tested for compatibility for cell culture use or any other applications in the early preclinical stage.
GMP-MG4S25 is the GMP version of this G4S-BLM25A1. These two proteins display indistinguishable performance profiles, thereby ensuring a seamless transition for end users from early preclinical stage to later clinical phases.

Rabbit IgG, Kappa

Biotinylated

1. Flow Cytometry (Evaluation of cell surface expressed CARs of varying specificity containing a G4S linker within the scFv of the extracellular domain).

2. Immunoassay of bispecific antibody.

3. CAR T cell enrichment and sorting.

It can specifically recognize proteins or ScFv containing (G3S)n or (G4S)n linkers, where n = 2, 3, 4... That is, it can recognize linkers with a minimum length of 2 repeats for both (G3S)n and (G4S)n.

Less than 0.01 EU per μg by the LAL method / rFC method.

<5 ppm of protein tested by ELISA.

<0.5 ng/μg of protein tested by ELISA.

<0.02 ng/μg of protein tested by qPCR.

Negative

Negative

Supplied as 0.2 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

This product is supplied and shipped with dry ice, please inquire the shipping cost.

For long term storage, the product should be stored at liquid state at -70°C.

Please avoid repeated freeze-thaw cycles.

• 2-8°C for 12 months under sterile conditions;
• -70°C for 24 months under sterile condition.

ACRO's Research-grade products are suitable for a wide range of cell culture applications, particularly for research use in academic institutions. These products are sterilized by filtration, followed by lyophilization where applicable. Typical specifications include endotoxin levels of <0.01 EU/μg and purities >95%. Biological activity is calibrated against WHO/NIBSC standards when available.
ACRO's Premium-grade (Pre-GMP) products are characterized by their high quality and enhanced safety profiles, making them ideal for early-stage discovery and manufacturing processes in cell therapy companies. A key advantage is their seamless transition to corresponding GMP-grade versions. Biological activity is calibrated against WHO/NIBSC standards when available. Typical specifications include endotoxin levels of <0.01 EU/μg and purities >95%. In addition, rigorous testing is conducted to ensure the absence of mycoplasma, HCD, and HCP, thereby guaranteeing product safety.