Monoclonal Anti-Influenza A [Wisconsin/67/2022] NA (H1N1) Antibody, Human IgG1 (4A2)

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Price
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NE1-MY2159-100ug
$350.00
In Stock - Delivery in 2-3 business days
NE1-MY2159-1mg (500ug X 2)
$2310.00
In Stock - Delivery in 2 weeks

Product Details

  • Source

    Chimeric Monoclonal Anti-Influenza A [Wisconsin/67/2022] NA (H1N1) Antibody, Human IgG1 (4A2) is recombinantly expressed in HEK293. It consists of mouse variable regions genetically fused to human IgG1 constant domains.

  • Antibody Type

    Recombinant Monoclonal

  • Clone

    4A2

  • Isotype

    Human IgG1, Kappa

  • Host Species

    Mouse

  • Reactivity

    Virus

  • Immunogen

    Recombinant Influenza A [Wisconsin/67/2022(H1N1)] Neuraminidase (NA) Protein is expressed from human 293 cells

  • Specificity

    Specifically recognizes Influenza A [Wisconsin/67/2022(H1N1)] Neuraminidase (NA).

  • Application

    Application
    Recommended Use / Performance
    ELISA
    0.2-2 μg/mL
  • Cross Verification

    This product No cross-reactivity in ELISA with
    Influenza B [Austria/1359417/2021] Neuraminidase (NA) Protein, His Tag (Cat. No. NEE-V5245).
    Influenza B [PHUKET/3073/2013] Neuraminidase (NA) Protein, His Tag (Cat. No. NEE-V5246).
    Influenza A [Darwin/6/2021] Neuraminidase (NA) Protein, His Tag (Cat. No. NEE-V5247).
    Influenza A [A/Darwin/9/2021 (H3N2)] Neuraminidase (NA) Protein, His Tag (Cat. No. NE2-V5249).
    Influenza A [turkey/Germany-MV/R2472/2014(H5N8)] Neuraminidase (NA) Protein, His Tag (Cat. No. NEE-V5249).
    Influenza A [Guangdong/18SF020(H5N6)] Neuraminidase (NA) Protein, His Tag (Cat. No. NEE-V524h).
    Influenza A (A/Sydney/1304/2022) Hemagglutinin (HA) Protein, His Tag (Cat. No. HA2-V52H9).
    Influenza A (A/Sydney/1304/2022) Neuraminidase (NA) Protein, His Tag (Cat. No. NE2-V5247).
    Influenza B (B/Singapore/INFTT-16-0610/2016) Neuraminidase (NA) Protein, His Tag (Cat. No. NEE-V524r).
    Influenza B (B/Singapore/WUH4618/2021) Neuraminidase (NA) Protein, His Tag (Cat. No. NEE-V524u).

  • Purification

    Protein A purified.

  • Aggregation

    Less than 10%, as determined by SEC-MALS.

  • Concentration

    Please refer to the Certificate of Analysis (CoA).

  • Form

    Lyophilized

  • Formulation

    Lyophilized from a 0.22 μm-filtered solution in PBS (pH 7.4), with trehalose as protectant.

    Please contact us for customized product forms or formulations.

  • Reconstitution

    Please refer to the Certificate of Analysis (CoA) for specific instructions.

  • Shipping

    Lyophilized product is shipped at ambient temperature.

  • Storage

    For long term storage, the product should be stored in a lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • Notices

    Product Specific Notices: For research use only.

  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • Bioactivity-ELISA

     Neuraminidase/NA (Influenza Virus) ELISA

    Immobilized Influenza A [Wisconsin/67/2022(H1N1)] Neuraminidase (NA) Protein, His Tag (Cat. No. NEE-V524m) at 1 μg/mL (100 μL/well) can bind Monoclonal Anti-Influenza A [Wisconsin/67/2022] NA (H1N1) Antibody, Human IgG1 (4A2) (Cat. No. NE1-MY2159) with a linear range of 0.06-4 ng/mL (QC tested).

    Protocol
  •  Neuraminidase/NA (Influenza Virus) ELISA

    Immobilized Influenza A [Sydney/5/2021] Neuraminidase (NA) Protein, His Tag (Cat. No. NEE-V5248), Influenza A [A/Victoria/4897/2022(H1N1)] Neuraminidase (NA) Protein, His Tag (Cat. No. NEE-V524c), Influenza A [Wisconsin/588/2019(H1N1)] Neuraminidase (NA) Protein, His Tag (Cat. No. NEE-V524k), Influenza A [Victoria/2570/2019(H1N1)] Neuraminidase (NA) Protein, His Tag (Cat. No. NEE-V524e), Influenza A (A/Georgia/12/2022 CVR-167) NA (A/pdm09 linage) Protein, His Tag (Cat. No. NEE-V524p) at 1 μg/mL (100 μL/well) can bind Monoclonal Anti-Influenza A [Wisconsin/67/2022] NA (H1N1) Antibody, Human IgG1 (4A2) (Cat. No. NE1-MY2159) with a linear range of 0.01-3 ng/mL (Routinely tested).

    Protocol

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FAQ

  • product

    Can lyophilized proteins remain stable during room-temperature shipping or temporary room-temperature exposure?

    In general, lyophilized proteins remain stable during room-temperature shipping or temporary exposure to room-temperature conditions.


    Many ACROBiosystems recombinant proteins are supplied in lyophilized (freeze-dried) form. The lyophilization process effectively removes moisture from the product, helping reduce degradation-related reactions and improve protein stability during transportation and storage.


    To evaluate the stability of lyophilized proteins under normal temperature conditions, ACROBiosystems conducted a stability study on 11 representative lyophilized protein products at 37°C. The study demonstrated that these proteins maintained good quality stability after storage at 37°C for approximately 20 days. Based on these validation results, temporary room-temperature exposure during shipping or handling is generally not expected to have a significant impact on product quality or downstream application performance.


    To ensure optimal long-term stability, products should be stored according to the storage conditions specified in the product Certificate of Analysis (COA) upon receipt.


    Supporting Document


Background

Neuraminidase (NA) and hemagglutinin (HA) are major membrane glycoproteins found on the surface of influenza virus. Hemagglutinin binds to the sialic acid-containing receptors on the surface of host cells during initial infection and at the end of an infectious cycle. Neuraminidase, on the other hand, cleaves the HA-sialic acid bondage from the newly formed virions and the host cell receptors during budding. Neuraminidase thus is described as a receptor-destroying enzyme which facilitates virus release and efficient spread of the progeny virus from cell to cell.

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