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Polyclonal Olig2 Antibody, Rabbit IgG

COADS MS
DS

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OL2-S456-20ul
$80.00
OL2-S456-100ul
$415.00
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Product Details

  • Source

    Polyclonal Olig2 Antibody, Rabbit IgG is a polyclonal antibody purified from rabbit serum.
    Gene Synonyms: Oligo2, bHLHe19, oligodendrocyte transcription factor 2.

  • Antibody Type

    Polyclonal Antibody

  • Isotype

    Rabbit IgG, Kappa

  • Host Species

    Rabbit polyclonal antibodies

  • Immunogen

    Mouse Olig2 peptide fused to GST

  • Specificity

    Usually, it is easier to get a positive signal in sections of juvenile animals than that of adults. This antibody does not recognize Olig1 and Olig3.

  • Application

    Application
    Recommended Usage
    IF
    1:200

  • Purification

    Protein A purified / Protein G purified.

  • Concentration

    Please refer to the Certificate of Analysis (CoA).

  • Form

    Liquid

  • Formulation

    Supplied a 0.22 μm-filtered solution in PBS containing 50 mM Glycine and 50 mM Tris, with 40% glycerol as protectant.

    Please contact us for customized product forms or formulations.

  • Storage

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. Shipped at -20°C. Store at -70°C for 12 months.

  • Notices

    Product Specific Notices: For research use only.

  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • Immunostaining

    Olig2 IMMUNOSTAINING

    2D cell staining: Immunofluorescent staining (10X) of cerebral organoid-derived neurons (CIPO-BWL001K) labeling Olig2 (Red) with purified OL2-S456 at 1:200 dilution. DAPI (blue) was used as nuclear counterstain.

  • Olig2 IMMUNOSTAINING

    3D organoid staining: Immunofluorescent staining (4x or 10X) of cerebral organoid-(CIPO-BWL001K) labeling Olig2 (Green) with purified OL2-S456 at 1:200 dilution. DAPI (blue) was used as nuclear counterstain. TUJ1 (red) is a neural differentiation marker commonly used to label neural processes.

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Background

The oligodendrocyte transcription factor 2 (Olig2) is a basic helix-loop-helix transcription factor which is highly expressed in the oligodendrocyte-lineage cells and in oligodendroglial tumors of the brain as well. Olig2 is an essential regulator of ventral neuroectodermal progenitor cell fate, especially regulating key stages of early oligodendrocyte development. Olig2 has also been reported to act as a gene repressor to determine the cell fate of motor neurons in the spinal cord. Olig2 is a useful marker for primary and mature oligodendrocytes as well as a marker of malignant glioma.

Zhang K, et al. Nat Commun. 2022;13(1):1423. doi: 10.1038/s41467-022-29068-z.

Ono K, et al. Mol Cells. 2009;27(4):397-401. doi: 10.1007/s10059-009-0067-2.

General Notes: FOR RESEARCH USE ONLY.

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