Monoclonal Anti-Sacituzumab Antibody, Mouse IgG1 (1H10)

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Cat. No. / Size
Price
Qty
SAB-MY2500a-100ug
$355.00
SAB-MY2500a-1mg (500ug X 2)
$2695.00
ETA of in-stock products:2 business days

Product Details

  • Source

    Monoclonal Anti-Sacituzumab Antibody, Mouse IgG1 (1H10) is a recombinant mouse monoclonal antibody expressed in HEK293 cells.

  • Antibody Type

    Recombinant Monoclonal

  • Clone

    1H10

  • Isotype

    Mouse IgG1, Kappa

  • Host Species

    Mouse

  • Specificity

    Specifically recognizes Human Sacituzumab; This antibody is a neutralizing antibody.

  • Purification

    Protein A purified / Protein G purified.

  • Aggregation

    Less than 5%, as determined by SEC-MALS.

  • Concentration

    Please refer to the Certificate of Analysis (CoA).

  • Form

    Lyophilized

  • Formulation

    Lyophilized from a 0.22 μm-filtered solution in PBS (pH 7.4), with trehalose as protectant.

    Please contact us for customized product forms or formulations.

  • Reconstitution

    Please refer to the Certificate of Analysis (CoA) for specific instructions.

  • Shipping

    Lyophilized product is shipped at ambient temperature.

  • Storage

    For long term storage, the product should be stored in a lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • Notices

    Product Specific Notices: For research use only.

  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • Bioactivity-ELISA

     Sacituzumab ELISA

    Immobilized Monoclonal Anti-Sacituzumab Antibody, Mouse IgG1 (1H10) (Cat. No. SAB-MY2500a) at 5 μg/mL, add Sacituzumab and then add Biotinylated Monoclonal Anti-Sacituzumab Antibody, Mouse IgG1 (1H7) (Cat. No. SAB-BLMY2501a) at 1 μg/mL. Detection was performed using HRP-conjugated Streptavidin (Acro, Cat. No. STN-NH913) (QC tested).

    Protocol

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Background

Sacituzumab is a genetically engineered humanized monoclonal antibody directed against the human trophoblast cell-surface antigen 2 (TROP2, also known as TACSTD2) found on the surface of normal epithelial cells and a broad range of malignant solid tumor cells. The antibody is an IgG1 kappa immunoglobulin containing murine complementarity-determining region (CDR) sequences within human framework regions of the variable domains and human constant region sequences. Sacituzumab is composed of two heavy chains of 449 amino acids and two light chains of 214 amino acids.

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