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Product Details
Product Details
This antibody panel comprises four distinct rabbit monoclonal antibodies against MMAE, with slight differences in their recognition epitopes. Consequently, they may exhibit varying affinity levels towards different MMAE analogs or different conjugates of MMAE and linkers. This panel can be used to conduct preliminary experiments for screening the optimal antibody clone.
Components
Cat.No.CloneSizeMME-MY2209M1H0920 ugMME-MY2210M1G0420 ugMME-MY2211M1D1220 ugMME-MY2198aM1H0520 ugSpecificity
Specifically recognizes MMAE and does not recognize MMAF.
Source
This panel contains four anti-MMAE monoclonal antibodies, suitable for pharmacokinetic (PK) detection of ADC with MMAE as the payload. All the anti-MMAE monoclonal antibodies are recombinantly expressed from HEK293, can be used as a capture antibody for detecting conjugated antibodies in ELISA assay.
Isotype
Rabbit IgG | Rabbit Kappa
Purification
Protein A purified / Protein G purified
Formulation
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
Reconstitution
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Storage
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
- -20°C to -70°C for 12 months in lyophilized state;
- -70°C for 3 months under sterile conditions after reconstitution.
ACRO Quality Management System
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Performance Data
Bioactivity-ELISA
Immobilized Monoclonal Anti-MMAE specific Antibody, Rabbit IgG (M1H09) (Cat. No. MME-MY2209) at 5 μg/mL, add Disitamab Vedotin (RC48) in the 100% Human Serum with a linear range of 0.016-0.98 μg/mL, and then add Biotinylated Human Her2, His,Avitag, premium grade (Cat. No. HE2-H82E2) at 0.5 μg/mL. Detection was performed using HRP-conjugated Streptavidin (Acro, Cat. No. STN-NH913) (QC tested).
Protocol
Immobilized Monoclonal Anti-MMAE specific Antibody, Rabbit IgG (M1G04) (Cat. No. MME-MY2210) at 5 μg/mL, add Disitamab Vedotin (RC48) in the 100% Human Serum with a linear range of 0.016-0.98 μg/mL, and then add Biotinylated Human Her2, His,Avitag, premium grade (Cat. No. HE2-H82E2) at 0.5 μg/mL. Detection was performed using HRP-conjugated Streptavidin (Acro, Cat. No. STN-NH913) (QC tested).
Protocol
Immobilized Monoclonal Anti-MMAE specific Antibody, Rabbit IgG (M1D12) (Cat. No. MME-MY2211) at 5 μg/mL, add Disitamab Vedotin (RC48) in the 100% Human Serum with a linear range of 0.016-0.98 μg/mL, and then add Biotinylated Human Her2, His,Avitag, premium grade (Cat. No. HE2-H82E2) at 0.5 μg/mL. Detection was performed using HRP-conjugated Streptavidin (Acro, Cat. No. STN-NH913) (QC tested).
Protocol
Immobilized Monoclonal Anti-MMAE specific Antibody, Rabbit IgG (M1H05) (Cat. No. MME-MY2198A) at 5 μg/mL, add Disitamab Vedotin (RC48) in the 100% Human Serum with a linear range of 0.016-0.98 μg/mL, and then add Biotinylated Human Her2, His,Avitag, premium grade (Cat. No. HE2-H82E2) at 0.5 μg/mL. Detection was performed using HRP-conjugated Streptavidin (Acro, Cat. No. STN-NH913) (QC tested).
Protocol
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