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Product Details
Synonym
ACE-2, ACEH, ACE2
Source
Paguma larvata ACE2, His Tag (AC2-P5248) is expressed from human 293 cells (HEK293). It contains AA Gln 18 - Thr 740 (Accession # Q56NL1-1).
Predicted N-terminus: His
Request for sequenceMolecular Characterization
Other Tags and Version Biotin & Other Labeled Version
This protein carries a polyhistidine tag at the N-terminus.
The protein has a calculated MW of 85.7 kDa. The protein migrates as 90-115 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin
Less than 1.0 EU per μg by the LAL method / rFC method.
Purity
>90% as determined by SDS-PAGE.
Formulation
Supplied as 0.2 μm filtered solution in 50 mM Tris, 150 mM NaCl, pH7.5 with glycerol as protectant.
Contact us for customized product form or formulation.
Shipping
This product is supplied and shipped with dry ice, please inquire the shipping cost.
Storage
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
- The product MUST be stored at -70°C or lower upon receipt;
- -70°C for 3 months under sterile conditions.
ACRO Quality Management System
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Performance Data
SDS-PAGE
Paguma larvata ACE2, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%.
Bioactivity-ELISA
Immobilized Paguma larvata ACE2, His Tag (Cat. No. AC2-P5248) at 2 μg/mL (100 μL/well) can bind SARS-CoV-2 S1 protein, Fc Tag (Cat. No. S1N-C5255) with a linear range of 0.156-5 μg/mL (Routinely tested).
Protocol
Immobilized Paguma larvata ACE2, His Tag (Cat. No. AC2-P5248) at 2 μg/mL (100 μL/well) can bind SARS-CoV-2 S protein RBD, Fc Tag (Cat. No. SPD-C5255) with a linear range of 0.078-5 μg/mL (Routinely tested).
Protocol
Bioactivity-SPR
Paguma larvata ACE2, His Tag (Cat. No. AC2-P5248) immobilized on CM5 Chip can bind SARS S protein RBD, His Tag (Cat. No. SPD-S52H6) with an affinity constant of 0.101 μM as determined in a SPR assay (Biacore T200) (QC tested).
Protocol
Paguma larvata ACE2, His Tag (Cat. No. AC2-P5248) immobilized on CM5 Chip can bind SARS-CoV-2 S protein RBD, His Tag (Cat. No. SPD-C52H3) with an affinity constant of 29 μM as determined in a SPR assay (Biacore T200) (Routinely tested).
Protocol
Paguma larvata ACE2, His Tag (Cat. No. AC2-P5248) immobilized on CM5 Chip can bind SARS-CoV-2 S1 protein, His Tag with an affinity constant of 47.5 μM as determined in a SPR assay (Biacore T200) (Routinely tested).
Protocol
Bioactivity-BLI
Loaded SARS-CoV-2 S protein RBD, Fc Tag (Cat. No. SPD-C5255) on Protein A Biosensor, can bind Paguma larvata ACE2, His Tag (Cat. No. AC2-P5248) with an affinity constant of 1.17 μM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).
Protocol
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Background
Recent Advances
Drug Development Progress- English Name：
Angiotensin-converting enzyme 2
- Category：
- Approved Drugs：
0 Details
- Drugs in Clinical Trials：
5 Details
- Highest Development Stage：
Phase 2 Clinical
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