Human ADORA2A Full Length Protein (VLP)

AIDD‑Ready
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ADA-H52P4-20ug
$620.00
ADA-H52P4-100ug
$1,235.00
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ADA-H52P4-500ug
$4,305.00
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ADA-H52P4
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  • Product Details
  • Performance Data
  • Reviews & Citations
  • Important Statement
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Application
  • Immunization
  • Cell based assay (FACS or functional assay)
  • Screening (ELISA)
Synonyms

ADORA2A, adenosine A2a receptor, A2aR, ADORA2, RDC8

Source

Human ADORA2A Full Length Protein-VLP (ADA-H52P4) is expressed from human 293 cells (HEK293). It contains AA Met 1 - Ser 412 (Accession # P29274-1).

Predicted N-terminus: Met 1

Molecular Characterization

*The isotype control of empty/mock VLP (Cat. No. VLP-N5213) is sold separately and not included in protein, you can follow the link for product information.

Structure

Virus-like particles (VLPs) are protein particles that mimic the shape of viruses but lack a viral genome, and incorporating transmembrane proteins on the external surface.

Synthesis Process

Envelope virus-like particles (eVLPs) are produced by co-expressing target membrane proteins with viral structural proteins in mammalian cells, enabling native embedding of membrane proteins into the lipid bilayer during VLP budding. This approach preserves authentic conformation, post-translational modifications, and orientation, while creating a completely detergent-free environment with repetitive multivalent display and strong immunogenicity making them ideal for immunization, binding assays in antibody discovery and screening (ELISA), and cell-based assays such as FACS, etc.

Endotoxin

Less than 1.0 EU per μg by the LAL method / rFC method.

Purity

>95% as determined by SEC-HPLC.

Formulation

The VLPs are highly immunogenic, so the immunization strategy should be optimized (antigen dose, regimen and adjuvant).

Supplied as 0.2 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

Shipping and Storage

This product is supplied and shipped on dry ice.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:
  • The product MUST be stored at -70°C or lower upon receipt;
  • -70°C for 12 months under sterile conditions.

Background

The Adenosine A2A Receptor, a GPCR highly expressed on immune cells within the hypoxic tumor microenvironment. Adenosine signaling via A2AR potently suppresses T cell activation and effector function. Antagonists of ADORA2A are in clinical development to reverse adenosine-mediated immunosuppression and enhance anti-tumor immunity.