HRP-Human CD3 epsilon Protein, His Tag

Customer Reviews
Cat. No. / Size
Price
Qty
CDE-HR2H4-25ug
$415.00
CDE-HR2H4-200ug
$1880.00
ETA of in-stock products:2 business days

Product Details

  • Synonyms

    FLJ18683, T3E, TCRE, CD3E, CD3-epsilon

  • Source

    HRP-Human CD3 epsilon, His Tag (CDE-HR2H4) is expressed from human 293 cells (HEK293). It contains AA Asp 23 - Asp 126 (Accession # P07766-1). It is the HRP labeled form of Human CD3 epsilon, His Tag.

    Predicted N-terminus: Asp 23

    Request for sequence
  • Molecular Characterization

    CD3 epsilon Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 12.6 kDa.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please protect from light and avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

Customers Also Viewed

Performance Data

  • Bioactivity-ELISA

     CD3 epsilon ELISA

    Immobilized Mouse Anti Human CD3(SP-34) at 1 μg/mL (100 μL/well) can bind HRP-Human CD3 epsilon, His Tag (Cat. No. CDE-HR2H4) with a linear range of 1-20 ng/mL (QC tested).

    Protocol
  •  CD3 epsilon ELISA

    Immobilized Human BCMA, His Tag (Cat. No. BCA-H522y) at 1 μg/mL (100 μL/well) can bind Bispecific BCMA×CD3 T cell-engaging Antibody with a linear range of 5-39 ng/mL when detected by HRP-Human CD3 epsilon, His Tag (Cat. No. CDE-HR2H4) (Routinely tested).

    Protocol
  • Bioactivity-SPR

     CD3 epsilon SPR

    Bispecific T-cell Engager captured on Protein A Chip can bind HRP-Human CD3 epsilon, His Tag (Cat. No. CDE-HR2H4) with an affinity constant of 4.45 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

    Protocol

Customer Reviews
Writing Reviews

Background

CD3e molecule, epsilon is also known as CD3E, is a T-cell surface single-pass type I membrane glycoprotein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. CD3E plays an essential role in T-cell development, and defects in CD3E gene cause severe immunodeficiency. CD3E gene has also been linked to a susceptibility to type I diabetes in women. CD3E has been shown to interact with TOP2B, CD3EAP and NCK2.

Recent Advances

 
Drug Development Progress
  • English Name:

    T-cell surface glycoprotein CD3 epsilon chain

  • Category:

  • Approved Drugs:

    4 Details

  • Drugs in Clinical Trials:

    7 Details

  • Highest Development Stage:

    Approved

Contact Us
Drug Candidate Licensing
More
  • Basic Product Information
  • Product Details
  • Customers Also Viewed
  • Performance Data
  • Customer Reviews
  • Background
Contact Us

[North America]: +1 800-810-0816
[Switzerland]: +41 800 040 012
[Asia & Pacific]: +86 400-682-2521

[North America]: 1 Innovation Way, Newark, DE 19711, USA
[Switzerland]: ACRObiosystems AG, c/o Zug Dammstrasse Centre AG, Dammstrasse 19, 6300 Zug Switzerland