Mouse CD38 Protein, His Tag (MALS verified)

Customer Reviews
Cat. No. / Size
Price
Qty
CD8-M5223-100ug
$360.00
CD8-M5223-1mg (250ug X 4)
$2615.00
ETA of in-stock products:2 business days

Product Details

  • Synonyms

    CD38, T10, cADPr hydrolase 1

  • Source

    Mouse CD38, His Tag (CD8-M5223) is expressed from human 293 cells (HEK293). It contains AA Leu 45 - Thr 304 (Accession # P56528-1).

    Predicted N-terminus: Leu 45

    Request for sequence
  • Molecular Characterization

    CD38 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 31.7 kDa. The protein migrates as 38-45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

    The protein is designed as a dimer.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >90% as determined by SDS-PAGE.

    >95% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in 50 mM MES, 100 mM NaCl, pH6.5 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • SDS-PAGE

    CD38 SDS-PAGE

    Mouse CD38, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%.

  • SEC-MALS

    CD38 SEC-MALS

    The purity of Mouse CD38, His Tag (Cat. No. CD8-M5223) is more than 95% and the molecular weight of this protein is around 80-105 kDa verified by SEC-MALS.

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Customer Reviews
Writing Reviews

  • Y***u2023-03-16
    Likes
    Used 3 ug/ml of this protein as the capture antigen in an ELISA assay to screen for anti-mouse CD38 mAbs. Very strong signal from the positive control anti-mouse CD38 mAb (clone: NIMR5) and no binding to several anti-human CD38 mAbs or the anti-IgG secondary Ab in the assay. The "ETD of in-stock products: 2 business days" statement on Acro website was accurate. Fast shipment. Professional COA and instructions on how to reconstitute and store this product.

Background

CD antigen CD38 is also known as ADP-ribosyl cyclase 1, which belongs to the ADP-ribosyl cyclase family. CD38 is expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma. CD38 is a multifunctional ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+ to ADP-ribose. These reaction products are essential for the regulation of intracellular Ca2+. The loss of CD38 function is associated with impaired immune responses, metabolic disturbances, and behavioral modifications. The CD38 protein is a marker of cell activation. It has been connected to HIV infection, leukemias, myelomas, solid tumors, type II diabetes mellitus and bone metabolism. CD38 has been used as a prognostic marker in leukemia.

Recent Advances

 
Drug Development Progress
  • English Name:

    Lymphocyte differentiation antigen CD38

  • Category:

  • Approved Drugs:

    3 Details

  • Drugs in Clinical Trials:

    47 Details

  • Highest Development Stage:

    Approved

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