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Mouse IL-1RL1 / ST2 Protein, Fc Tag

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Cat. No. / Size
Price
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IL1-M5259-200ug
$360.00
IL1-M5259-1mg
$1650.00
ETA of in-stock products:2 business days
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Product Details

  • Synonyms

    IL1RL1, DER4, FIT-1, IL33R, ST2, ST2L, ST2V, T1

  • Source

    Mouse IL-1RL1, Fc Tag (IL1-M5259) is expressed from human 293 cells (HEK293). It contains AA Ser 27 - Arg 332 (Accession # P14719-1).

    Predicted N-terminus: Ser 27

    Request for sequence
  • Molecular Characterization

    IL-1RL1 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a human IgG1 Fc tag at the C-terminus.

    The protein has a calculated MW of 61.5 kDa. The protein migrates as 80-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • SDS-PAGE

    IL-1RL1 SDS-PAGE

    Mouse IL-1RL1, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

  • Bioactivity-ELISA

     IL-1RL1 ELISA

    Immobilized Mouse IL-33, His Tag (Cat. No. IL3-M5245) at 10 μg/mL (100 μL/well) can bind Mouse IL-1RL1, Fc Tag (Cat. No. IL1-M5259) with a linear range of 0.001-0.156 μg/mL (QC tested).

    Protocol

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Background

Interleukin 1 receptor-like 1 (IL1RL1) is also known as ST2, DER4, FIT-1, IL33R, ST2L, ST2V, which belongs to the interleukin-1 receptor family. IL1RL1 contains three Ig-like C2-type (immunoglobulin-like) domains and one TIR domain. IL1RL1 is receptor for interleukin-33 (IL-33), its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. IL1RL1 possibly involved in helper T-cell function. IL1RL1 can interact with MYD88, IRAK1, IRAK4, and TRAF6.

Recent Advances

 
Drug Development Progress
  • English Name:

    Interleukin-1 receptor-like 1

  • Category:

  • Approved Drugs:

    0 Details

  • Drugs in Clinical Trials:

    5 Details

  • Highest Development Stage:

    NDA/BLA

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