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Human IL-33 (2-270) Protein, His Tag

COADS MS
DS

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IL3-H51H3-50ug
$400.00
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IL3-H51H3-1mg
$3120.00
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Product Details

  • Synonyms

    IL33, DV27, C9ORF26, IL1F11, NFHEV, DKFZp586H0523, DVS27, NFEHEV, RP11-575C20.2

  • Source

    Human IL-33 (2-270) Protein, His Tag (IL3-H51H3) is expressed from E. coli cells. It contains AA Lys 2 - Thr 270 (Accession # O95760-1).

    Predicted N-terminus: Met

    Request for sequence

  • Molecular Characterization

    IL-33 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 32.6 kDa. The protein migrates as 8 kDa,29 kDa and 33-35 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Supplied as 0.2 μm filtered solution in PBS, Arginine, pH7.4 with glycerol as protectant.

    Contact us for customized product form or formulation.

  • Shipping and Storage

    This product is supplied and shipped on dry ice.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. The product MUST be stored at -70°C or lower upon receipt;
    2. -70°C for 12 months under sterile conditions.

  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • SDS-PAGE

    IL-33 SDS-PAGE

    Human IL-33 (2-270) Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • Bioactivity-ELISA

    IL-33 ELISA

    Immobilized Human IL-1RL1, Fc Tag (Cat. No. IL1-H5250) at 5 μg/mL (100 μL/well) can bind Human IL-33 (2-270) Protein, His Tag (Cat. No. IL3-H51H3) with a linear range of 0.01-0.625 μg/mL (QC tested).

    Protocol

  • Bioactivity-BLI

    IL-33 BLI

    Loaded Human IL-1RL1, Fc Tag (Cat. No. IL1-H5250) on Protein A Biosensor, can bind Human IL-33 (2-270) Protein, His Tag (Cat. No. IL3-H51H3) with an affinity constant of 15.1 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

    Protocol

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Background

Interleukin 33 (IL33) is known as C9orf26, DKFZp586H0523, DVS27, NF-HEV, NFEHEV, RP11-575C20.2,and is a cytokine belonging to the IL-1 superfamily. IL-33 induces helper T cells, mast cells, eosinophils and basophils to produce type 2 cytokines. IL-33 mediates its biological effects by interacting with the receptors ST2 (aka IL1RL1) and IL-1 Receptor Accessory Protein (IL1RAP), activating intracellular molecules in the NF-κB and MAP kinase signaling pathways that drive production of type 2 cytokines (e.g. IL-5 and IL-13) from polarized Th2 cells. In vivo, IL-33 induces the expression of IL-4, IL-5, and IL-13 and leads to severe pathological changes in mucosal organs.

Recent Advances

 
Drug Development Progress
  • English Name：

    Interleukin-33

  • Category：

  • Approved Drugs：

    0 Details

  • Drugs in Clinical Trials：

    9 Details

  • Highest Development Stage：

    Phase 3 Clinical

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  • Background