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Human IL-36Ra Protein, Tag Free (HPLC & SPR verified)

AIDD‑Ready
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ILA-H5117-100ug
$310.00
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ILA-H5117-1mg (500ug X 2)
$2,245.00
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ILA-H5117
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Product Details
Performance Data
Reviews & Citations
Resources
  • Product Details
  • Performance Data
  • Reviews & Citations
  • Important Statement
  • Resources
Synonyms

IL-36Ra, FIL1 delta, IL-1RP3, IL-1HY1, IL-1 delta, IL-1F5, IL-1L1, IL1F5, IL36Ra, IL36RN

Source

Human IL-36Ra Protein, Tag Free (ILA-H5117) is expressed from E. coli cells. It contains AA Val 2 - Asp 155 (Accession # Q9UBH0).

Predicted N-terminus: Val

Molecular Characterization
Other Tags and Version Biotin & Other Labeled Version

This protein carries no "tag".

The protein has a calculated MW of 16.8 kDa. The protein migrates as 15-16 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE).

Endotoxin

Less than 1.0 EU per μg by the LAL method / rFC method.

Purity

>95% as determined by SDS-PAGE.

>90% as determined by SEC-HPLC.

Formulation

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

Reconstitution

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

Shipping and Storage

This product is shipped at ambient temperature.

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:
  • -20°C to -70°C for 12 months in lyophilized state;
  • -70°C for 3 months under sterile conditions after reconstitution.
ACRO Quality Management System

Background

The IL-36 subfamily of cytokines is the most diverse, including three agonists(IL-36α, IL-36β, and IL-36γ), one antagonist(IL-36Ra), one cognate receptor(IL-36R) and one accessory protein(IL-1RAcP). The receptor activation follows a two-step mechanism in that the agonist first binds to IL-36R and the resulting binary complex recruits IL-1RAcP. IL-36Ra inhibits the activity of IL-36 (IL-36α, IL-36β, and IL-36γ) by binding to the receptor IL-36R and preventing IL-36R from associating with the coreceptor IL-1RAcP for signaling.