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Product Details
Synonyms
MASP3, MASP1, CRARF1, RaRF
Source
Human MASP3 (450-721), His Tag (MA3-H52H3) is expressed from human 293 cells (HEK293). It contains AA Ile 450 - Val 721 (Accession # P48740-2).
Predicted N-terminus: Ile 450
Request for sequenceMolecular Characterization
Other Tags and Version Biotin & Other Labeled Version
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 31.6 kDa. The protein migrates as 38-45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin
Less than 1.0 EU per μg by the LAL method / rFC method.
Purity
>95% as determined by SDS-PAGE.
Formulation
Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 150 mM NaCl, pH7.5 with trehalose as protectant.
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Reconstitution
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Shipping and Storage
This product is shipped at ambient temperature.
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
- -20°C to -70°C for 12 months in lyophilized state;
- -70°C for 3 months under sterile conditions after reconstitution.
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Performance Data
SDS-PAGE
Human MASP3 (450-721), His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.
Bioactivity
Measured by its ability to cleave a colorimetric peptide substrate, N-carbobenzyloxy-Lys-ThioBenzyl ester (Z-Lys-SBzl), in the presence of 5,5’Dithio-bis (2-nitrobenzoic acid) (DTNB).The specific activity is >7500 pmol/min/µg,as measured under the described conditions (QC tested).
Protocol
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Background
discovered as complexes with mannose-binding lectin (MBL) and therefore named MBL-associated
serine proteases, but later, they were found to interact with ficolins, and later still, collectin-10
and collectin-11. As well as proteolytic enzymes (MASP-1, MASP-2, MASP-3), the group includes
non-enzymatic factors (MAp19, MAp44). In this review, the association-specific factors of the lectin
pathway with haematologic malignancies and related infections are discussed.
Recent Advances
Drug Development Progress- English Name：
Mannan-binding lectin serine protease 1
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- Drugs in Clinical Trials：
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