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Human Mucin-1 / MUC-1 (24-380) Protein, His Tag (MALS verified)

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Cat. No. / Size
Price
Qty
MU1-H52H7-100ug
$415.00
MU1-H52H7-1mg (500ug X 2)
$2930.00
ETA of in-stock products:2 business days
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Product Details

  • Synonyms

    Mucin 1, MUC1, CD227, EMA, H23AG, KL-6, MAM6, MUC-1, SEC, MUC-1, X, MUC1, ZD, PEM, PEMT, PUM, CA15-3, Episialin

  • Source

    Human Mucin-1 (24-380) Protein, His Tag (MU1-H52H7) is expressed from human 293 cells (HEK293). It contains AA Ser 24 - Ser 380 (Accession # P15941-1).

    Predicted N-terminus: Ser 24

    Request for sequence
  • Molecular Characterization

    Mucin-1 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 35.6 kDa. The protein migrates as 55-150 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 0.1 EU per μg by the LAL method / rFC method.

  • Purity

    >95% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • SDS-PAGE

    Mucin-1 SDS-PAGE

    Human Mucin-1 (24-380) Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    Mucin-1 SEC-MALS

    The purity of Human Mucin-1 (24-380) Protein, His Tag (Cat. No. MU1-H52H7) is more than 90% and the molecular weight of this protein is around 45-65 kDa verified by SEC-MALS.

    Report
  • Bioactivity-ELISA

     Mucin-1 ELISA

    Immobilized Human Mucin-1 (24-380) Protein, His Tag (Cat. No. MU1-H52H7) at 2 μg/mL (100 μL/well) can bind Anti-Mucin-1 Antibody, Mouse IgG1 (SM-3) with a linear range of 4-63 ng/mL (QC tested).

    Protocol

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Background

This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants

Recent Advances

 
Drug Development Progress
  • English Name:

    Mucin-1

  • Category:

  • Approved Drugs:

    0 Details

  • Drugs in Clinical Trials:

    28 Details

  • Highest Development Stage:

    Phase 2 Clinical

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