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Influenza A virus (Sydney/1359/2024)& (Singapore/GP20238/2024) NA (H3N2) Protein, His Tag

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Cat. No. / Size
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NA2-V5243-100ug
$350.00
NA2-V5243-1mg
$2680.00
ETA of in-stock products:2 business days
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Product Details

  • Synonym

    NA, Neuraminidase

  • Source

    Influenza A virus (Sydney/1359/2024)& (Singapore/GP20238/2024) NA (H3N2) Protein, His Tag (NA2-V5243) is expressed from human 293 cells (HEK293). It contains AA Lys 80 - Thr 469 (Accession # EPI_ISL_19711425 & EPI_ISL_19871656, GISAID).

    Predicted N-terminus: Lys 80

    Request for sequence

  • Molecular Characterization

    Neuraminidase (NA) Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the N-terminus.

    The protein has a calculated MW of 55.9 kDa. The protein migrates as 70-95 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Supplied as 0.2 μm filtered solution in 50 mM Tris, 500 mM NaCl, pH7.5 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Shipping

    This product is supplied and shipped with dry ice, please inquire the shipping cost.

  • Storage

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. The product MUST be stored at -70°C or lower upon receipt;
    2. -70°C for 3 months under sterile conditions.

  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • SDS-PAGE

    Neuraminidase (NA) SDS-PAGE

    Influenza A virus (Sydney/1359/2024)& (Singapore/GP20238/2024) NA (H3N2) Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95% (With Star Ribbon Pre-stained Protein Marker).

  • Bioactivity-SPR

    Neuraminidase (NA) SPR

    a-Neu5Ac-PAA-biotin immobilized on SA Chip can bind Influenza A virus (Sydney/1359/2024)& (Singapore/GP20238/2024) NA (H3N2) Protein, His Tag (Cat. No. NA2-V5243) with an affinity constant of 27.0 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

    Protocol

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Background

Neuraminidase (NA) and hemagglutinin (HA) are major membrane glycoproteins found on the surface of influenza virus. Hemagglutinin binds to the sialic acid-containing receptors on the surface of host cells during initial infection and at the end of an infectious cycle. Neuraminidase, on the other hand, cleaves the HA-sialic acid bondage from the newly formed virions and the host cell receptors during budding. Neuraminidase thus is described as a receptor-destroying enzyme which facilitates virus release and efficient spread of the progeny virus from cell to cell.

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Drug Development Progress
  • English Name：

    Neuraminidase

  • Category：

  • Approved Drugs：

    4 Details

  • Drugs in Clinical Trials：

    5 Details

  • Highest Development Stage：

    Approved

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