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Human NPR1 / NPRA Protein, Fc Tag (MALS verified)

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Cat. No. / Size
Price
Qty
NP1-H5259-100ug
$430.00
NP1-H5259-1mg (500ug X 2)
$3170.00
ETA of in-stock products:2 business days
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Product Details

  • Synonyms

    Atrial natriuretic peptide receptor 1, NPR1, NPRA, GC-A, ANPRA, NPR-A

  • Source

    Human NPR1, Fc Tag (NP1-H5259) is expressed from human 293 cells (HEK293). It contains AA Gly 33 - Glu 473 (Accession # P16066-1).

    Predicted N-terminus: Gly 33

    Request for sequence
  • Molecular Characterization

    NPR1 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a human IgG1 Fc tag at the C-terminus.

    The protein has a calculated MW of 75.3 kDa. The protein migrates as 90-120 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Purity

    >95% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • SDS-PAGE

    NPR1 SDS-PAGE

    Human NPR1, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    NPR1 SEC-MALS

    The purity of Human NPR1, Fc Tag (Cat. No. NP1-H5259) is more than 90% and the molecular weight of this protein is around 190-230 kDa verified by SEC-MALS.

    Report
  • Bioactivity-ELISA

     NPR1 ELISA

    Immobilized Human NPR1, Fc Tag (Cat. No. NP1-H5259) at 1 μg/mL (100 μL/well) can bind Anti-NPR1 hIgG4 Antibody with a linear range of 0.2-16 ng/mL (QC tested).

    Protocol

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Background

Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand.

Recent Advances

 
Drug Development Progress
  • English Name:

    Natriuretic peptide receptor 1

  • Category:

  • Approved Drugs:

    4 Details

  • Drugs in Clinical Trials:

    7 Details

  • Highest Development Stage:

    Approved

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