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Cynomolgus PADI2 Protein, His Tag (MALS verified)

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PA2-C5545-50ug
$620.00
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PA2-C5545-1mg
$4,760.00
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PA2-C5545
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  • Product Details
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Synonyms

PADI2, PAD-H19, KIAA0994, PAD2, PDI2

Source

Cynomolgus PADI2, His Tag (PA2-C5545) is expressed from Baculovirus-Insect cells. It contains AA Met 1 - Pro 665 (Accession # A0A2K5TST4-1).

Predicted N-terminus: Met

Molecular Characterization
Other Tags and Version Biotin & Other Labeled Version

This protein carries a polyhistidine tag at the N-terminus.

The protein has a calculated MW of 77.6 kDa. The protein migrates as 75-85 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

The protein is designed as a dimer.

Endotoxin

Less than 1.0 EU per μg by the LAL method / rFC method.

Purity

>95% as determined by SDS-PAGE.

Formulation

Supplied as 0.2 μm filtered solution in PBS, pH7.4 with glycerol as protectant.

Contact us for customized product form or formulation.

Shipping and Storage

This product is supplied and shipped on dry ice.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:
  • The product MUST be stored at -70°C or lower upon receipt;
  • -70°C for 3 months under sterile conditions.
ACRO Quality Management System

Background

Protein-arginine deiminase type-2 (PADI2) are calcium-dependent histone-modifying enzymes whose activity is dysregulated in inflammatory diseases and cancer. This enzyme which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The type II enzyme is the most widely expressed family member. Known substrates for this enzyme include myelin basic protein in the central nervous system and vimentin in skeletal muscle and macrophages.