Human Parkin Protein, His Tag

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Cat. No. / Size
Price
Qty
PAN-H5543-100ug
$340.00
PAN-H5543-500ug
$1280.00
ETA of in-stock products:2 business days

Product Details

  • Synonyms

    AR-JP, LPRS2, PARK2, PDJ

  • Source

    Human Parkin Protein, His Tag (PAN-H5543) is expressed from Baculovirus-Insect cells. It contains AA Ile 2 - Val 465 (Accession # O60260-1).

    Predicted N-terminus: Met

    Request for sequence
  • Molecular Characterization

    Parkin Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the N-terminus.

    The protein has a calculated MW of 53.5 kDa. The protein migrates as 55-60 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Purity

    >85% as determined by SDS-PAGE.

  • Formulation

    Supplied as 0.2 μm filtered solution in 50 mM Tris, 150 mM NaCl, pH7.5 with glycerol as protectant.

    Contact us for customized product form or formulation.

  • Shipping

    This product is supplied and shipped with dry ice, please inquire the shipping cost.

  • Storage

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. The product MUST be stored at -70°C or lower upon receipt;
    2. -70°C for 3 months under sterile conditions.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • SDS-PAGE

    Parkin SDS-PAGE

    Human Parkin Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 85% (With Star Ribbon Pre-stained Protein Marker).

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Background

Parkin is an E3 ubiquitin ligase encoded by the PARK2 gene, comprising 465 amino acids and containing an N‑terminal ubiquitin‑like domain and C‑terminal RING domains. It plays a pivotal role in the ubiquitin–proteasome system, tagging damaged or misfolded proteins for degradation. Parkin is essential for mitophagy, the selective clearance of dysfunctional mitochondria, thereby maintaining cellular homeostasis. Mutations in PARK2 cause autosomal recessive juvenile Parkinson’s disease, leading to dopaminergic neuron loss. Beyond neuroprotection, Parkin influences apoptosis regulation and cellular stress responses. Its dysfunction is linked to mitochondrial impairment, protein aggregation, and neurodegeneration, making it a key target in Parkinson’s disease research

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