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Cynomolgus Plasma Kallikrein / KLKB1 Protein, His Tag (active enzyme, MALS verified)

Cat. No. / Size
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KL1-C52H3-20ug
$315.00
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KL1-C52H3-100ug
$924.00
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KL1-C52H3-500ug
$3,150.00
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KL1-C52H3
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Product Details
Performance Data
Reviews & Citations
Resources
  • Product Details
  • Performance Data
  • Reviews & Citations
  • Important Statement
  • Resources
Synonyms

Fletcher factor, kallikrein B, plasma (Fletcher factor) 1, kininogenin, KLK3 plasma kallikrein, KLKB1, plasma kallikrein heavy chain, plasma kallikrein light chain, Plasma Kallikrein, Plasma Prekallikrein, PPK, KLKB1

Source

Cynomolgus Plasma Kallikrein Protein, His Tag (KL1-C52H3) is expressed from human 293 cells (HEK293). It contains AA Gly 20 - Ala 638 (Accession # A0A2K5VTJ9).

Predicted N-terminus: Gly 20

Molecular Characterization
Other Tags and Version Biotin & Other Labeled Version

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 71.0 kDa. The protein migrates as 80-95 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Endotoxin

Less than 1.0 EU per μg by the LAL method / rFC method.

Purity

>95% as determined by SDS-PAGE.

>95% as determined by SEC-MALS.

Formulation

Supplied as 0.2 μm filtered solution in 50 mM Tris, 150 mM NaCl, pH7.5 with glycerol as protectant.

Contact us for customized product form or formulation.

Shipping and Storage

This product is supplied and shipped on dry ice.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:
  • The product MUST be stored at -70°C or lower upon receipt;
  • -70°C for 12 months under sterile conditions.
ACRO Quality Management System

Background

Human Plasma Kallikrein, a serine protease, is synthesized in the liver and circulates in the plasma by binding to high molecular weight (HMW) kininogen or as a free zymogen. The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.