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Cynomolgus Prolactin R Protein, His Tag (MALS verified)

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Cat. No. / Size
Price
Qty
PRR-C52H3-100ug
$360.00
PRR-C52H3-1mg (500ug X 2)
$2615.00
ETA of in-stock products:2 business days
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Product Details

  • Synonyms

    Prolactin R, PRLR, PRL-R

  • Source

    Cynomolgus Prolactin R Protein, His Tag (PRR-C52H3) is expressed from human 293 cells (HEK293). It contains AA Gln 25 - Thr 236 (Accession # A0A2K5WXK1).

    Predicted N-terminus: Gln 25

    Request for sequence
  • Molecular Characterization

    Prolactin R Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 26.5 kDa. The protein migrates as 32-38 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >95% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Shipping and Storage

    This product is shipped at ambient temperature.

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • SDS-PAGE

    Prolactin R SDS-PAGE

    Cynomolgus Prolactin R Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    Prolactin R SEC-MALS

    The purity of Cynomolgus Prolactin R Protein, His Tag (Cat. No. PRR-C52H3) is more than 90% and the molecular weight of this protein is around 27-37 kDa verified by SEC-MALS.

    Report
  • Bioactivity-ELISA

     Prolactin R ELISA

    Immobilized Biotinylated Human Prolactin, Fc,Avitag (Cat. No. PRN-H82F7) at 1 μg/mL (100 μL/well) on streptavidin (Cat. No. STN-N5116) precoated (0.5 μg/well) plate can bind Cynomolgus Prolactin R Protein, His Tag (Cat. No. PRR-C52H3) with a linear range of 1-39 ng/mL (QC tested).

    Protocol

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Background

The prolactin receptor (PRLR) is a transmembrane protein belonging to the class I cytokine receptor superfamily, widely expressed in mammary gland, reproductive organs, liver, and brain. Signal activation is initiated when a single prolactin (PRL) molecule binds to this pre-dimerized PRLR, inducing a specific conformational change. This triggers the associated JAK2 kinases to phosphorylate each other and the receptor, ultimately leading to the recruitment and activation of downstream STAT5 transcription factors. This precise mechanism governs essential physiological processes, including lactation, reproduction, metabolism, and immune function, and its dysregulation is implicated in diseases such as certain cancers and endometriosis.

Recent Advances

 
Drug Development Progress
  • English Name:

    Prolactin receptor

  • Category:

  • Approved Drugs:

    0 Details

  • Drugs in Clinical Trials:

    2 Details

  • Highest Development Stage:

    Phase 3 Clinical

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