Mouse PVRIG Protein, Fc Tag (MALS verified)

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Cat. No. / Size
Price
Qty
PVG-M5257-100ug
$390.00
PVG-M5257-1mg (250ug X 4)
$2720.00
ETA of in-stock products:2 business days

Product Details

  • Synonyms

    C7orf15, C7orf15MGC138295, CD112R, MGC104322, MGC138297, MGC2463, PVRIG, CD112 receptor

  • Source

    Mouse PVRIG, Fc Tag (PVG-M5257) is expressed from human 293 cells (HEK293). It contains AA Ser 35 - Asp 165 (Accession # A0A1B0GS01-1).

    Predicted N-terminus: Ser 35

    Request for sequence
  • Molecular Characterization

    PVRIG Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a human IgG1 Fc tag at the C-terminus.

    The protein has a calculated MW of 40.6 kDa. The protein migrates as 48-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >95% as determined by SDS-PAGE.

    >95% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Shipping and Storage

    This product is shipped at ambient temperature.

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • SDS-PAGE

    PVRIG SDS-PAGE

    Mouse PVRIG, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

  • SEC-MALS

    PVRIG SEC-MALS

    The purity of Mouse PVRIG, Fc Tag (Cat. No. PVG-M5257) is more than 95% and the molecular weight of this protein is around 85-110 kDa verified by SEC-MALS.

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Background

Human PVRIG (poliovirus receptor related immunoglobulin domain-containing protein), also known as CD112 receptor (CD112R), is an approximately 34 kDa single transmembrane protein in the poliovirus receptor-like protein (PVR) family. The CD112R gene encodes a putative single transmembrane protein, which is composed of a single extracellular IgV domain, one transmembrane domain, and a long intracellular domain. Notably, the intracellular domain of phatases. The extracellular domain sequence of human and mouse CD112R have 65.3% similarity. CD112R may act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals.

Recent Advances

 
Drug Development Progress
  • English Name:

    Transmembrane protein PVRIG

  • Category:

  • Approved Drugs:

    0 Details

  • Drugs in Clinical Trials:

    7 Details

  • Highest Development Stage:

    Phase 2 Clinical

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