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Human RIPK2 Protein, GST Tag (active enzyme)

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RI2-H55G3-10ug
$338.00
In Stock - Delivery in 2-3 weeks
RI2-H55G3-50ug
$1,220.00
In Stock - Delivery in 2-3 weeks
RI2-H55G3-500ug
$2,680.00
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RI2-H55G3
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Product Details
Performance Data
Reviews & Citations
Resources
  • Product Details
  • Performance Data
  • Reviews & Citations
  • Important Statement
  • Resources
Synonyms

CARD3, CARDIAK, CCK, GIG30, RICK, RIP2

Source

Human RIPK2 Protein, GST Tag (RI2-H55G3) is expressed from Baculovirus-Insect cells. It contains AA Met 1 - Glu 299 (Accession # O43353).

Predicted N-terminus: Met 1

Molecular Characterization
Other Tags and Version Biotin & Other Labeled Version

This protein carries a GST tag at the C-terminus.

The protein has a calculated MW of 59.7 kDa. The protein migrates as 58-65 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Endotoxin

Less than 1.0 EU per μg by the LAL method / rFC method.

Purity

>80% as determined by SDS-PAGE.

Formulation

Supplied as 0.2 μm filtered solution in 50 mM Tris, 150 mM NaCl, pH7.5 with glycerol as protectant.

Contact us for customized product form or formulation.

Shipping and Storage

This product is supplied and shipped on dry ice.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:
  • The product MUST be stored at -70°C or lower upon receipt;
  • -70°C for 3 months under sterile conditions.
ACRO Quality Management System

Background

Receptor-interacting protein kinase 2 (RIPK2) is a crucial downstream signaling node for NOD1 and NOD2 intracellular pattern recognition receptors. Upon activation, RIPK2 drives NF-κB and MAPK pathways, triggering robust pro-inflammatory cytokine production. Dysregulation of RIPK2 is strongly linked to autoimmune and inflammatory disorders, particularly Crohn's disease, making it a highly attractive target for novel kinase inhibitors and PROTAC degraders.