Human SDF-1 / CXCL12 Protein, Research GradeResearch use only

  • This product is designed for academic and scientific research institutions.
Customer Reviews
Cat. No. / Size
Price
Qty
SD1-H5116-20ug
$200.00
SD1-H5116-50ug
$300.00
SD1-H5116-1mg (200ug X 5)
$2500.00
ETA of in-stock products:2 business days

Product Details

  • Features and Advantages

    1. Native Conformation: Native sequences, tag-free and natural function.
    2. Reliable Activity: Biological activity calibrated against WHO/NIBSC standards.
    3. Stringent Quality Control: Protein content, purity, and cell-based bioactivity testing for each batch.
    4. Lowest Endotoxin level (<0.01 EU/ug).
    5. Safety Assurance: Sterile filtration through 0.2 μm membrane.
    6. AOF: Animal origin-free raw materials throughout the production process.
  • Synonyms

    SDF-1, CXCL12, hSDF-1, IRH, hIRH, PBSF, SDF1, SDF1A, SDF1B

  • Source

    Human SDF-1 Protein, Research Grade (SD1-H5116) is expressed from E. coli cells. It contains AA Lys 22 - Lys 89 (Accession # P48061-2).

    Predicted N-terminus: Met

    Request for sequence
  • Molecular Characterization

    SDF-1 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries no "tag".

    The protein has a calculated MW of 8.1 kDa. The protein migrates as 10 kDa±3 kDa under reducing (R) condition, and 15 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under non-reducing (NR) condition (SDS-PAGE).

  • Endotoxin

    Less than 0.01 EU per μg by the LAL method / rFC method.

  • Purity

    >95% as determined by SDS-PAGE.

    >95% as determined by SEC-HPLC.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process
  • Quality Description

    ACRO's Research-grade products are suitable for a wide range of cell culture applications, particularly for research use in academic institutions. These products are sterilized by filtration, followed by lyophilization where applicable. Typical specifications include endotoxin levels of <0.01 EU/μg and purities >95%. Biological activity is calibrated against WHO/NIBSC standards when available.
    ACRO's Premium-grade (Pre-GMP) products are characterized by their high quality and enhanced safety profiles, making them ideal for early-stage discovery and manufacturing processes in cell therapy companies. A key advantage is their seamless transition to corresponding GMP-grade versions. Biological activity is calibrated against WHO/NIBSC standards when available. Typical specifications include endotoxin levels of <0.01 EU/μg and purities >95%. In addition, rigorous testing is conducted to ensure the absence of mycoplasma, HCD, and HCP, thereby guaranteeing product safety.

Customers Also Viewed

Performance Data

  • SDS-PAGE

    SDF-1 SDS-PAGE

    Human SDF-1 Protein, Research Grade on SDS-PAGE under reducing (R) and non-reducing (NR) conditions. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-HPLC

    SDF-1 SEC-HPLC

    The purity of Human SDF-1 Protein, Research Grade (Cat. No. SD1-H5116) was greater than 95% as determined by SEC-HPLC.

  • Bioactivity-ELISA

     SDF-1 ELISA

    Immobilized Human SDF-1 Protein, Research Grade (Cat. No. SD1-H5116) at 5 μg/mL (100 μL/well) can bind Human CXCR4, Fc Tag (Cat. No. CX4-H5269) with a linear range of 0.04-2.5 μg/mL (Routinely tested).

    Protocol
  • Bioactivity-SPR

     SDF-1 SPR

    Human CXCR4 Full Length Protein, Flag,His Tag (Cat. No. CX4-H52D3) immobilized on CM5 Chip can bind Human SDF-1 Protein, Research Grade (Cat. No. SD1-H5116) with an affinity constant of 516 nM as determined in a SPR assay (in presence of Buffer B) (Biacore 8K) (QC tested).

    Protocol

Customer Reviews
Writing Reviews

Background

Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation. Stimulates the proliferation of bone marrow-derived B-cell progenitors in the presence of IL7 as well as growth of stromal cell-dependent pre-B-cells

Recent Advances

 
Drug Development Progress
  • English Name:

    C-X-C motif chemokine ligand 12

  • Category:

  • Approved Drugs:

    0 Details

  • Drugs in Clinical Trials:

    6 Details

  • Highest Development Stage:

    Phase 2 Clinical

Contact Us
Drug Candidate Licensing
More
  • Basic Product Information
  • Product Details
  • Customers Also Viewed
  • Performance Data
  • Customer Reviews
  • Background
Contact Us

[North America]: +1 800-810-0816
[Switzerland]: +41 800 040 012
[Asia & Pacific]: +86 400-682-2521

[North America]: 1 Innovation Way, Newark, DE 19711, USA
[Switzerland]: ACRObiosystems AG, c/o Zug Dammstrasse Centre AG, Dammstrasse 19, 6300 Zug Switzerland