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SARS-CoV-2 S protein, His Tag, Super stable trimer (MALS verified)

COADS MS
DS

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Cat. No. / Size
Price
Qty
SPN-C52H7-200ug
$1485.00
SPN-C52H7-1mg
$5080.00
SPN-C52H7-10mg (5mg X 2)
$36915.00
SPN-C52H7-100mg
$295320.00
ETA of in-stock products:2 business days
Sub-Total$ 0
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Product Details

  • Synonym

    Spike, S protein, Spike glycoprotein, S glycoprotein

  • Source

    SARS-CoV-2 S protein, His Tag, Super stable trimer (SPN-C52H7) is expressed from human 293 cells (HEK293).

    Predicted N-terminus: Val 16

    Request for sequence

  • Molecular Characterization

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 138.0 kDa. The protein migrates as 170-250 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >95% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Supplied as 0.2 μm filtered solution in 0.1 M Sodium citrate, pH5.5.

    Contact us for customized product form or formulation.

  • Shipping

    This product is supplied and shipped with dry ice, please inquire the shipping cost.

  • Storage

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. The product MUST be stored at -70°C or lower upon receipt;
    2. -70°C for 3 months under sterile conditions.

  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • SDS-PAGE

    Spike protein SDS-PAGE

    SARS-CoV-2 S protein, His Tag, Super stable trimer on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

  • SEC-MALS

    Spike protein SEC-MALS

    The purity of SARS-CoV-2 S protein, His Tag, Super stable trimer (Cat. No. SPN-C52H7) is more than 90% and the molecular weight of this protein is around 480-550 kDa verified by SEC-MALS.

    Report

  • Bioactivity-ELISA

    Spike protein ELISA

    Immobilized Human ACE2, Fc Tag (Cat. No. AC2-H5257) at 1 μg/mL (100 μL/well) can bind SARS-CoV-2 S protein, His Tag, Super stable trimer (Cat. No. SPN-C52H7) with a linear range of 0.2-6 ng/mL (QC tested).

    Protocol

  • Spike protein ELISA

    Immobilized Anti-SARS-CoV-2 RBD Neutralizing Antibody, Human IgG1 (Cat. No. SAD-S35) at 1 μg/mL (100 μL/well) can bind SARS-CoV-2 S protein, His Tag, Super stable trimer (Cat. No. SPN-C52H7) with a linear range of 0.2-6 ng/mL (Routinely tested).

    Protocol

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Background

It's been reported that SARS-CoV-2 can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.

Recent Advances

 
Drug Development Progress
  • English Name：

    Coronavirus spike glycoprotein

  • Category：

  • Approved Drugs：

    10 Details

  • Drugs in Clinical Trials：

    72 Details

  • Highest Development Stage：

    Approved

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