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Product Details
Synonyms
LTA, DAMA-25N12, 13-004, LT, TNFB, TNFSF1, LT-alpha, TNF-beta
Source
Human TNF-beta Protein, Fc Tag (TNB-H5263) is expressed from human 293 cells (HEK293). It contains AA Lys 62 - Leu 205 (Accession # P01374).
Predicted N-terminus: Pro
Request for sequenceMolecular Characterization
Other Tags and Version Biotin & Other Labeled Version
This protein carries a human IgG1 Fc tag at the N-terminus.
The protein has a calculated MW of 42.3 kDa. The protein migrates as 48-53 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
The protein is designed as a trimer.
Endotoxin
Less than 1.0 EU per μg by the LAL method / rFC method.
Purity
>90% as determined by SDS-PAGE.
Formulation
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
Reconstitution
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Storage
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
- -20°C to -70°C for 12 months in lyophilized state;
- -70°C for 3 months under sterile conditions after reconstitution.
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Performance Data
SDS-PAGE
Human TNF-beta Protein, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).
SEC-MALS
The purity of Human TNF-beta Protein, Fc Tag (Cat. No. TNB-H5263) is more than 85% and the molecular weight of this protein is around 255-285 kDa verified by SEC-MALS.
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Bioactivity-ELISA
Immobilized Human TNFR2, His Tag (Cat. No. TN2-H5227) at 5 μg/mL (100 μL/well) can bind Human TNF-beta Protein, Fc Tag (Cat. No. TNB-H5263) with a linear range of 0.2-5 ng/mL (QC tested).
Protocol
Immobilized Human HVEM, His Tag (Cat. No. HVM-H52E9) at 5 μg/mL (100 μL/well) can bind Human TNF-beta Protein, Fc Tag (Cat. No. TNB-H5263) with a linear range of 0.2-5 ng/mL (Routinely tested).
Protocol
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Background
Recent Advances
Drug Development Progress- English Name：
Tumor necrosis factor β
- Category：
- Approved Drugs：
18 Details
- Drugs in Clinical Trials：
7 Details
- Highest Development Stage：
Approved
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