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Human TOP2A / TOP2 Protein, Tag Free

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Cat. No. / Size
Price
Qty
TOA-H5117-20ug
$310.00
TOA-H5117-100ug
$1010.00
TOA-H5117-500ug
$3625.00
ETA of in-stock products:2 business days
Sub-Total$ 0

Product Details

  • Synonyms

    TOP2A, TOP2, DNA topoisomerase 2-alpha, DNA topoisomerase II, alpha isozyme

  • Source

    Human TOP2A, Tag Free (TOA-H5117) is expressed from E. coli cells. It contains AA Ser 1354 - Ser 1473 (Accession # P11388-1).

    Predicted N-terminus: Met

    Request for sequence
  • Molecular Characterization

    TOP2A Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries no "tag".

    The protein has a calculated MW of 13.0 kDa. The protein migrates as 20 kDa under reducing (R) condition (SDS-PAGE).

  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Supplied as 0.2 μm filtered solution in 50 mM Tris, 0.5 M KCl, pH8.0 with glycerol as protectant.

    Contact us for customized product form or formulation.

  • Shipping and Storage

    This product is supplied and shipped on dry ice.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. The product MUST be stored at -70°C or lower upon receipt;
    2. -70°C for 3 months under sterile conditions.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • SDS-PAGE

    TOP2A SDS-PAGE

    Human TOP2A, Tag Free on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%.

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FAQ

  • Product

    What is the extinction coefficient of this product?

    The sequence of this product (including the target region and tags) contains no Trp, Tyr, or Cys residues; therefore, its extinction coefficient is 0.

Background

DNA topoisomerase 2-alpha (TOP2A) is also known as DNA topoisomerase II, alpha isozyme and TOP2. It is a topoisomerase which control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes. May play a role in regulating the period length of ARNTL/BMAL1 transcriptional oscillation. Also it is the targets of anti-cancer drugs that cause treatment-related leukemias with balanced translocations.

Recent Advances

 
Drug Development Progress
  • English Name:

    Topoisomerase (DNA) II alpha

  • Category:

  • Approved Drugs:

    1 Details

  • Drugs in Clinical Trials:

    1 Details

  • Highest Development Stage:

    Approved

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