user
menu
letter
Sign InRegister
langEnglisharrow

Human TrkA / NTRK1 (192-402) Protein, Mouse IgG2a Fc Tag

Related Products: Cell line CHEK-ATF093
Cat. No. / Size
Price
Availability
Qty
TRA-H5253-100ug
$310.00
In Stock - Delivery in 1-2 business days
TRA-H5253-1mg (500ug X 2)
$2,245.00
In Stock - Delivery in 2 weeks
TRA-H5253
Sub-Total :
$ 0
Customize Product Request Quote
Contact Us
Contact Us
Sub-Total:
$ 0
Request Quote
Product Details
Performance Data
Reviews & Citations
Resources
  • Product Details
  • Performance Data
  • Reviews & Citations
  • Important Statement
  • Resources
Synonyms

TrkA, NTRK1, MTC, TRK, TRKA, Trk-A

Source

Human TrkA (192-402), Mouse IgG2a Fc Tag (TRA-H5253) is expressed from human 293 cells (HEK293). It contains AA Gly 192 - Val 402 (Accession # P04629-2).

Predicted N-terminus: Gly 192

Molecular Characterization
Other Tags and Version Biotin & Other Labeled Version

This protein carries a mouse IgG2a Fc tag at the C-terminus.

The protein has a calculated MW of 49.1 kDa. The protein migrates as 70-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Endotoxin

Less than 0.1 EU per μg by the LAL method / rFC method.

Purity

>95% as determined by SDS-PAGE.

Formulation

Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5 with trehalose as protectant.

Contact us for customized product form or formulation.

Reconstitution

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

Shipping and Storage

This product is shipped at ambient temperature.

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:
  • -20°C to -70°C for 12 months in lyophilized state;
  • -70°C for 3 months under sterile conditions after reconstitution.
ACRO Quality Management System

Background

Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand. Can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors.