Save Product
Product Details
Application
In in vivo CAR research, the endocytic capacity of tLNP is a key factor for evaluation of the delivery efficiency. Our pH Sensitive Anti-G4S Linker Labeling Reagent (Cat. G4S-PZF25C1) specifically binds to the scFv format antibody (containing G4S linker), and the pH-sensitive dye can significantly enhance the fluorescence signal in an acidic environment. This enables flow cytometry to assess the endocytic efficiency of LNPs conjugated with the scFv-format antibody (containing G4S linker).
Features
- High signal-to-noise ratio – Strong fluorescence signal with minimal background
- Application validated – FACS-ready for tLNP uptake studies
- Universal – Target independent
Storage
Please protect from light and avoid repeated freeze-thaw cycles.
This product is stable after storage at:
- This product is stable after storage at:
- -70°C for 12 months from date of receipt.
Shipping
This product is supplied and shipped with dry ice, please inquire the shipping cost.
ACRO Quality Management System
Customers Also Viewed
Performance Data
Bioactivity-Flow Cytometry
tLNP-hCD8 scFv Ab (contain a G4S linker) or Isotype Control LNP were labeled with pH Sensitive Anti-G4S Linker Labeling Reagent (Cat. No. G4S-PZF25C1). CD3+ T cells were separately treated with pH Sensitive Dye Labeled tLNP-hCD8 scFv Ab (G4S containing) or isotype control conjugates for 4 hours. APC signal was measured by flow cytometry to evaluate the tLNP internalization (Routinely tested).
Protocol
Customer Reviews Writing Reviews
Recent Advances
Contact Us
[North America]: +1 800-810-0816
[Switzerland]: +41 800 040 012
[Asia & Pacific]: +86 400-682-2521
Drug Candidate Licensing
