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ACROBiosystems

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Background

MHC I (Major histocompatibility complex class I), also known as HLA in humans, is a diverse set of cell surface receptors expressed on all nucleated cells in the body. It plays a crucial role in the adaptive immune system. In vivo, MHC I can bind with antigen peptide fragments of intact proteins. The peptide-MHC complex is recognized by the antigen-specific receptors of T lymphocytes, and upon recognition, activated T cells will contribute to the immune response and does help for clear infection. MHC I-displayed peptidome that allows for highly specific T cell-mediated responses which are vitally important for adaptive immunity. Therefore, research on the deep relationship between peptide-MHC I complex and TCR is increasingly significant for the mechanism investigation and drug development.

Positioned as a reliable partner to provide key reagents for biologic drug discovery and development, ACROBiosystems can provide the customized peptide-MHC I complex service to accelerate your relevant research.

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Service Features

Professional MHC-peptide complex R&D technology platform

HEK 293 expression systems

Various types of MHC I and antigens are available

Monomer/Tetramer forms

FITC/PE/APC/Biotin-labeled are optional

Mature bioactivity verification platform: SPR/ELISA/FACS and more

Customized Product List

MHC Allele	Target
HLA-A0101 HLA-A0201 HLA-A0301 HLA-A1101 HLA-A2402 HLA-A3303 HLA-B1501 HLA-B1525 HLA-B3802 HLA-B4601 HLA-B*0702 ……	NY-ESO-1 GP-100 MSLN AFP WT1 MAGE-A1 HPV HBV HIV EBV PRAME ……

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High binding affinity verified by SPR

Anti-NY-ESO-1 antibody captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind Biotinylated Human HLA-A0201 NY-ESO-1 (SLLMWITQC) Complex Protein (Cat. No. HL1-H82E6) with an affinity constant of 16.9 nM as determined in a SPR assay (Biacore 8K) (QC tested).

Protocol

Anti-NY-ESO-1 antibody captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind Human HLA-A0201 NY-ESO-1 (SLLMWITQC) Tetramer Protein (Cat. No. HL1-H52E8) with an affinity constant of 1.35 nM as determined in a SPR assay (Biacore 8K) (QC tested).

Protocol

Biotinylated Human HLA-C*07:02:01 & B2M & RYR ,His,Avitag™&Tag Free (Cat. No. HLR-H52W2) immobilized on SA Chip can bind Human KIR2DL3, Fc Tag (Cat. No. KI3-H5258) with an affinity constant of 2.40 μM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Protocol

Biotinylated Human HLA-C*07:02:01 & B2M & RYR ,His,Avitag™&Tag Free (Cat. No. HLR-H52W2) immobilized on SA Chip can bind Human KIR2DL2, Fc Tag (Cat. No. KI2-H5255) with an affinity constant of 1.01 μM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Protocol

High binding affinity verified by ELISA

Immobilized Biotinylated Human HLA-A*02:01 NY-ESO-1 (SLLMWITQC) Complex Protein (Cat. No. HL1-H82E6) at 1 μg/mL (100 μL/well) on streptavidin (Cat. No. STN-N5116) precoated (0.5 μg/well) plate can bind Anti-NY-ESO-1 Antibody, Human IgG1 with a linear range of 0.1-8 ng/mL (QC tested).

Protocol

Immobilized Biotinylated Human HLA-A*02:01 NY-ESO-1 (SLLMWITQV) Complex Protein (Cat. No. HL1-H82E4) at 1 μg/mL (100 μL/well) on streptavidin (Cat. No. STN-N5116) precoated (0.5 μg/well) plate can bind Anti-NY-ESO-1 Antibody, Human IgG1 with a linear range of 0.2-16 ng/mL (QC tested).

Protocol

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References

1.Thomas C, Tampé R. MHC I assembly and peptide editing - chaperones, clients, and molecular plasticity in immunity. Curr Opin Immunol. 2021 Jun;70:48-56. doi: 10.1016/j.coi.2021.02.004. Epub 2021 Mar 6. PMID: 33689959.
2.Becar M, Kasi A. Physiology, MHC Class I. 2021 Sep 28. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan–. PMID: 32310482.