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ASGR1

ASGR1 Overview

English NameAsialoglycoprotein receptor 1Approved Drugs0
Drugs in Clinical Trials1Target SynonymHL-1,C-type lectin domain family 4 member H1,Hepatic lectin H1,ASGPR 1,ASGR1,Asialoglycoprotein Receptor 1,CLEC4H1,ASGP-R 1,ASGPR1
Highest Development StagePhase 2 Clinical
English NameAsialoglycoprotein receptor 1
Target SynonymHL-1,C-type lectin domain family 4 member H1,Hepatic lectin H1,ASGPR 1,ASGR1,Asialoglycoprotein Receptor 1,CLEC4H1,ASGP-R 1,ASGPR1
Approved Drugs0
Drugs in Clinical Trials1
Highest Development StagePhase 2 Clinical

ASGR1 Background

ASGPR, a transmembrane C-type lectin, recognizes a wide variety of ligands that contain either terminal galactose (Gal) or N-acetylgalactosamine (GalNAc) residues and has been identified as a highly selective receptor on hepatocytes. The ASGR is composed of both a major (ASGR1) and minor subunit (ASGR2). ASGR1 has been shown to be efficiently targeted to the plasma membrane and to undergo constitutive endocytosis and recycling and found mainly expressed in the human liver.

ASGR1 Synonyms

ASGP-R 1, ASGPR 1, C-type lectin domain family 4 member H1, Hepatic lectin H1, HL-1

Clinical Drug Information

English NameResearch CodeHighest Development StageCompanyIndicationClinical Trial
Kylo-11Kylo-11; Kylo11Phase 2 ClinicalShanghai Hejiya Biopharmaceutical Co Ltd, Xiamen Ganbaoli Biopharmaceutical Co LtdAtherosclerosis; Cardiovascular Diseases; Hyperlipoproteinemias; Lipid Metabolism Disorders
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Product Reviews

  • N***i2024-11-25
    1People Like
    I recently purchased the hASGPR protein from Acro Biosystems for use in my SPR (surface plasmon resonance) experiments, and I am thrilled with the results! The protein quality was excellent, and it delivered reliable and reproducible data, which significantly boosted the confidence in my study. The purity and functional activity of the hASGPR were clearly top-notch, making it easy to work with and yielding strong, clean sensorgrams. I am particularly impressed with how well it performed in terms of binding affinity and kinetics analysis, which was a critical aspect of my research. Shipping was also quick, and the product was well-packaged to maintain its integrity. Overall, I highly recommend this product to anyone conducting SPR experiments requiring hASGPR. Great product and great experience!
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