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ENPP-2

ENPP-2 Overview

English NameEctonucleotide pyrophosphatase/phosphodiesterase 2Approved Drugs0
Drugs in Clinical Trials9Target SynonymEC:3.1.4.39，ATX，Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 2，Phosphodiesterase I/Nucleotide Pyrophosphatase 2，Plasma Lysophospholipase D，Autotaxin-T，EC 3.1.4.39，PD-IALPHA，ATX-X，NPP2，E-NPP 2，Autotaxin，ENPP2，PDNP2，Ectonucleotide Pyrophosphatase/Phosphodiesterase 2，Extracellular Lysophospholipase D，LysoPLD
Highest Development StagePhase 2 Clinical
English NameEctonucleotide pyrophosphatase/phosphodiesterase 2
Target SynonymEC:3.1.4.39，ATX，Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 2，Phosphodiesterase I/Nucleotide Pyrophosphatase 2，Plasma Lysophospholipase D，Autotaxin-T，EC 3.1.4.39，PD-IALPHA，ATX-X，NPP2，E-NPP 2，Autotaxin，ENPP2，PDNP2，Ectonucleotide Pyrophosphatase/Phosphodiesterase 2，Extracellular Lysophospholipase D，LysoPLD
Approved Drugs0
Drugs in Clinical Trials9
Highest Development StagePhase 2 Clinical

ENPP-2 Product List

  • Product Category

    Protein (1)

  • Product Status

    Launched (1)

  • Species

    Human (1)

  • Tag

    His Tag (1)

  • Conjugate

    Unconjugated (1)

Cat. No.SpeciesHostProduct DescriptionStructurePurityFeatureOrder Now
EN2-H5241
Human
HEK293
Human ENPP-2 / Autotaxin Protein, His Tag (active enzyme)
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Total: 1
  • 1

ENPP-2 Background

Autotaxin also known as ectonucleotide pyrophosphatase / phosphodiesterase family member 2 (E-NPP 2 or ENPP2), Extracellular lysophospholipase D (LysoPLD), Autotaxin (ATX or ATX-X), which belongs to the nucleotide pyrophosphatase / phosphodiesterase family. ENPP2 contains two SMB (somatomedin-B) domains. ENPP2 hydrolyzes lysophospholipids to produce lysophosphatidic acid (LPA) in extracellular fluids. ENPP2 can act on sphingosylphosphphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. ENPP2 stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein.

ENPP-2 Synonyms

ENPP-2,E-NPP 2,Autotaxin,LysoPLD,ATX,PDNP2,ATX-X,NPP2,PD-IALPHA

Clinical Drug Information

English NameResearch CodeHighest Development StageCompanyIndicationClinical Trial
BBT-877BBT-877Phase 2 ClinicalLegochemIdiopathic Pulmonary Fibrosis
Details
CambritaxestatCRT-0273750; IOA-289Phase 2 ClinicalCancer Research Technology, Merck & CoPancreatic Neoplasms; Solid tumours
Details
HRS-9813HRS-9813; HRS9813Phase 2 ClinicalGuangdong Hengrui Pharmaceutical Co LtdIdiopathic Pulmonary Fibrosis; Pulmonary Fibrosis
Details
HW-021199HW-021199Phase 2 ClinicalHubei Bio-Pharmaceutical Industrial Technological Institute Inc, Humanwell Puracap (Likang) Pharmaceuticals Co LtdIdiopathic Pulmonary Fibrosis
Details
HNC664HNC664; HNC-664Phase 1 ClinicalGuangzhou Henovcom Bioscience Co LtdIdiopathic Pulmonary Fibrosis; Pancreatic Neoplasms
Details
CudetaxestatPAT-409; BLD-0409Phase 1 ClinicalBlade Therapeutics IncIdiopathic Pulmonary Fibrosis; Liver Diseases; Metabolic Dysfunction-Associated Steatotic Liver Disease
Details
NXC-680NXC-680Phase 1 ClinicalNextgen Bioscience IncIdiopathic Pulmonary Fibrosis
Details
HNC-1058HNC-1058Phase 1 ClinicalGuangzhou Henovcom Bioscience Co LtdIdiopathic Pulmonary Fibrosis
Details
FTP-198FTP-198Phase 1 ClinicalHaisco Pharmaceutical Group Co LtdIdiopathic Pulmonary Fibrosis
Details
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