IL-11 R alpha

Interleukin-11 receptor subunit alpha (IL-11RA) is a type I transmembrane hematopoietic cytokine receptor serving as the ligand-specific binding subunit for IL-11. It harbors an extracellular cytokine-binding homology region, binds IL-11 with low affinity on its own, and recruits the shared, ubiquitously expressed signal-transducing coreceptor gp130 to assemble a functional high-affinity hexameric signaling complex upon ligand engagement. Widely expressed on stromal, epithelial and hematopoietic cells, IL-11RA mediates activation of JAK/STAT (predominantly STAT3), MAPK and PI3K pathways, governing critical biological processes including hematopoiesis, tissue damage repair and immune homeostasis, and is closely linked to fibrotic disorders and tumor progression.

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