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IL-1RL1

IL-1RL1 Overview

English NameInterleukin-1 receptor-like 1Approved Drugs0
Drugs in Clinical Trials5Target SynonymST2，IL1RL1，Protein ST2，DER4，T1，Interleukin 1 Receptor Like 1，Homolog Of Mouse Growth Stimulation-Expressed，Interleukin 1 Receptor-Related Protein，Growth Stimulation-Expressed，FIT-1，IL33R，ST2L，ST2V，Interleukin-1 Receptor-Like 1 Protein，EC:3.2.2.6，Interleukin-1 Receptor-Like 1
Highest Development StageNDA/BLA
English NameInterleukin-1 receptor-like 1
Target SynonymST2，IL1RL1，Protein ST2，DER4，T1，Interleukin 1 Receptor Like 1，Homolog Of Mouse Growth Stimulation-Expressed，Interleukin 1 Receptor-Related Protein，Growth Stimulation-Expressed，FIT-1，IL33R，ST2L，ST2V，Interleukin-1 Receptor-Like 1 Protein，EC:3.2.2.6，Interleukin-1 Receptor-Like 1
Approved Drugs0
Drugs in Clinical Trials5
Highest Development StageNDA/BLA

IL-1RL1 Product List

  • Product Category

    Protein (5)

  • Product Status

    Launched (5)

  • Species

    Human (4)Mouse (1)

  • Tag

    His Tag (1)Fc Tag (2)His Tag & Avi Tag (1)Fc Tag & Avi Tag (1)

  • Conjugate

    Unconjugated (3)Biotin-labeled (2)

Cat. No.SpeciesHostProduct DescriptionStructurePurityFeatureOrder Now
HOT
IL1-H5229
Human
HEK293
Human IL-1RL1 / ST2 Protein, His Tag, low endotoxin (MALS verified)
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HOT
IL1-H5250
Human
HEK293
Human IL-1RL1 / ST2 Protein, Fc Tag
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HOT
IL1-H82E9
Human
HEK293
Biotinylated Human IL-1RL1 / ST2 Protein, His,Avitag™ (MALS verified)
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HOT
IL1-M5259
Mouse
HEK293
Mouse IL-1RL1 / ST2 Protein, Fc Tag
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IL1-H82F8
Human
HEK293
Biotinylated Human IL-1RL1 / ST2 Protein, Fc,Avitag™ (MALS verified)
 Add to Cart
Total: 5
  • 1

IL-1RL1 Background

Interleukin 1 receptor-like 1 (IL1RL1) is also known as ST2, DER4, FIT-1, IL33R, ST2L, ST2V, which belongs to the interleukin-1 receptor family. IL1RL1 contains three Ig-like C2-type (immunoglobulin-like) domains and one TIR domain. IL1RL1 is receptor for interleukin-33 (IL-33), its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. IL1RL1 possibly involved in helper T-cell function. IL1RL1 can interact with MYD88, IRAK1, IRAK4, and TRAF6.

IL-1RL1 Synonyms

IL1RL1,DER4,FIT-1,IL33R,ST2,ST2L,ST2V,T1

Clinical Drug Information

English NameResearch CodeHighest Development StageCompanyIndicationClinical Trial
AstegolimabAMG-282; RG-6149; RO-7187807Phase 3 ClinicalAmgen Inc, F. Hoffmann-La Roche LtdCoronavirus Disease 2019 (COVID-19); Dermatitis, Atopic; Pulmonary Disease, Chronic Obstructive
Details
AK-139AK139; AK-139Phase 2 ClinicalKangfang Biotechnology (Cayman) Co LtdAsthma; Chronic rhinosinusitis with nasal polyps (CRSwNP); Chronic Urticaria; Dermatitis, Atopic; Hypersensitivity; Prurigo Nodularis; Pulmonary Disease, Chronic Obstructive; Rhinitis, Allergic; Rhinitis, Allergic, Seasonal
Details
TQC-2938TQC2938; TQC-2938Phase 2 ClinicalNanjing Shunxin Pharmaceuticals Co Ltd Of Chiatai Tianqing Pharmaceutical GroupAsthma; Pulmonary Disease, Chronic Obstructive; Rhinitis, Allergic, Seasonal
Details
Recombinant humanized anti-ST2 monoclonal antibody9-MW1911; 9MW-1911; 9-MW-1911; 9MW1911Phase 2 ClinicalMabwell (Shanghai) Bioscience Co LtdAsthma; Dermatitis, Atopic; Pulmonary Disease, Chronic Obstructive
Details
NEROFEPhase 1 ClinicalImmune System Key LtdNeoplasms; Solid tumours
Details
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