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Integrin alpha V beta 6

Integrin alpha V beta 6 Overview

English NameIntegrin alpha-V/beta-6Approved Drugs0
Drugs in Clinical Trials6Target Synonym
Highest Development StagePhase 3 Clinical
English NameIntegrin alpha-V/beta-6
Target Synonym
Approved Drugs0
Drugs in Clinical Trials6
Highest Development StagePhase 3 Clinical

Integrin alpha V beta 6 Product List

  • Product Category

    Protein (8)Cell (2)

  • Product Status

    Launched (10)

  • Species

    Human (4)Mouse (2)Cynomolgus (2)Rat (1)Mouse & Human (1)

  • Tag

    His Tag (5)His Tag & Avi Tag (3)- (2)

  • Conjugate

    Unconjugated (5)Biotin-labeled (3)- (2)

Total: 10
  • 1

Integrin alpha V beta 6 Background

Integrin alpha V beta 6 is a heterodimer of beta-6 associating with alpha-V. Integrin alpha-V beta-6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. Also, Integrin alpha-V beta-6 acts as a receptor for coxsackievirus A9 and coxsackievirus B1 as well as herpes simplex virus-1/HHV-1. Furthermore, it binds the TGF-beta latency‑associated peptide (LAP) and activates TGF-beta 1 or TGF-beta 3 from large latent complexes. This activation requires interaction with LTBP-1 and fibronectin, and is enhanced by PAR-1.

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