Integrin αvβ6 Proteins & Cell Lines

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Integrin alpha V beta 6 Overview

Molecule Name

Integrin alpha-V/beta-6

Drug Development Progress

Drugs in Clinical Trials6

Approved Drugs0

Highest Development StagePhase 2 Clinical

Target Synonym

Background

Integrin alpha V beta 6 is a heterodimer of beta-6 associating with alpha-V. Integrin alpha-V beta-6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. Also, Integrin alpha-V beta-6 acts as a receptor for coxsackievirus A9 and coxsackievirus B1 as well as herpes simplex virus-1/HHV-1. Furthermore, it binds the TGF-beta latency‑associated peptide (LAP) and activates TGF-beta 1 or TGF-beta 3 from large latent complexes. This activation requires interaction with LTBP-1 and fibronectin, and is enhanced by PAR-1.

Integrin alpha V beta 6 Product List

Molecule	Cat. No.	Product Name	Species	Host	Purity	Activity	Size&Price
Integrin alpha V beta 6	HOTAIDD‑Ready IT6-H52E1	Human Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein, His Tag&Tag Free, low endotoxin (MALS verified)	Human	HEK293	MALSSDS-PAGE	ELISASPR	$485.00 100ug
Integrin alpha V beta 6	HOTAIDD‑Ready IT6-M52W9	Mouse Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein, His Tag&Tag Free (MALS verified)	Mouse	HEK293	MALSSDS-PAGE	ELISABLI	$485.00 100ug
Integrin alpha V beta 6	HOTAIDD‑Ready IT6-C52W9	Cynomolgus Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein, His Tag&Tag Free, low endotoxin (MALS verified)	Cynomolgus	HEK293	MALSSDS-PAGE	ELISASPR	$485.00 100ug
Integrin alpha V beta 6	HOTAvitag IT6-H82E4	Biotinylated Human Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein, His,Avitag™&Tag Free (MALS verified)	Human	HEK293	MALSSDS-PAGE	ELISA	$435.00 25ug
Integrin alpha V beta 6	Avitag IT6-C82E3	Biotinylated Cynomolgus Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein, His,Avitag™&Tag Free	Cynomolgus	HEK293	SDS-PAGE	ELISA	$360.00 25ug
Integrin alpha V beta 6	IT6-M52E3	Mouse & Human Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein, His Tag&Tag Free, low endotoxin (MALS verified)	Mouse & Human	HEK293	MALSSDS-PAGE	ELISA	$485.00 100ug
Integrin alpha V beta 6	Avitag IT6-M82W9	Biotinylated Mouse Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein, His,Avitag™&Tag Free (MALS verified)	Mouse	HEK293	MALSSDS-PAGE	ELISA	$360.00 25ug
Integrin alpha V beta 6	IT6-R52E6	Rat Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein, His Tag&Tag Free (MALS verified)	Rat	HEK293	MALSSDS-PAGE	ELISA	$420.00 100ug

Integrin alpha V beta 6 >

HotAIDD‑Ready

Human Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein, His Tag&Tag Free, low endotoxin (MALS verified)

Cat. No. IT6-H52E1

Species

Human

Host

HEK293

Purity

MALSSDS-PAGE

Activity

ELISASPR

$485.00

Integrin alpha V beta 6 >

HotAIDD‑Ready

Mouse Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein, His Tag&Tag Free (MALS verified)

Cat. No. IT6-M52W9

Species

Mouse

Host

HEK293

Purity

MALSSDS-PAGE

Activity

ELISABLI

$485.00

Integrin alpha V beta 6 >

HotAIDD‑Ready

Cynomolgus Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein, His Tag&Tag Free, low endotoxin (MALS verified)

Cat. No. IT6-C52W9

Species

Cynomolgus

Host

HEK293

Purity

MALSSDS-PAGE

Activity

ELISASPR

$485.00

Integrin alpha V beta 6 >

HotAvitag

Biotinylated Human Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein, His,Avitag™&Tag Free (MALS verified)

Cat. No. IT6-H82E4

Species

Human

Host

HEK293

Purity

MALSSDS-PAGE

Activity

ELISA

$435.00

Integrin alpha V beta 6 >

Avitag

Biotinylated Cynomolgus Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein, His,Avitag™&Tag Free

Cat. No. IT6-C82E3

Species

Cynomolgus

Host

HEK293

Purity

SDS-PAGE

Activity

ELISA

$360.00

Integrin alpha V beta 6 >

Mouse & Human Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein, His Tag&Tag Free, low endotoxin (MALS verified)

Cat. No. IT6-M52E3

Species

Mouse & Human

Host

HEK293

Purity

MALSSDS-PAGE

Activity

ELISA

$485.00

Integrin alpha V beta 6 >

Avitag

Biotinylated Mouse Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein, His,Avitag™&Tag Free (MALS verified)

Cat. No. IT6-M82W9

Species

Mouse

Host

HEK293

Purity

MALSSDS-PAGE

Activity

ELISA

$360.00

Integrin alpha V beta 6 >

Rat Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein, His Tag&Tag Free (MALS verified)

Cat. No. IT6-R52E6

Species

Rat

Host

HEK293

Purity

MALSSDS-PAGE

Activity

ELISA

$420.00

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FAQ

How should αVβ6 cross-species binding be assessed before animal studies?

Screen against human αVβ6, then compare the homolog from the intended model, such as cynomolgus, mouse, or rat. Use matched heterodimer formats and assay conditions to avoid construct-driven differences.

When should recombinant αVβ6 protein and an αVβ6 stable cell line be used together?

Recombinant αVβ6 supports controlled affinity and biochemical inhibition assays. A stable cell line then confirms recognition of membrane-displayed αVβ6 and reveals accessibility or avidity effects.

Why is a MALS-verified αVβ6 heterodimer important for inhibitor screening?

The binding surface depends on the assembled αV and β6 subunits. SEC-MALS helps confirm the expected molecular assembly and detect aggregation that could distort multivalent binding signals.

How should RGD-ligand and divalent-cation conditions be controlled in αVβ6 assays?

αVβ6 recognition is RGD- and conformation-dependent, and Ca²⁺, Mg²⁺, or Mn²⁺ can alter apparent affinity. Keep ligand source, cation composition, and chelator content constant across candidates and lots.

How can direct αVβ6 blockade be distinguished from downstream TGF-β pathway inhibition?

Measure disruption of the αVβ6–latent TGF-β1 interaction first, using a binding assay such as TR-FRET. Follow with a cell-based TGF-β readout to determine whether pathway inhibition is consistent with direct target blockade.

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Resources

Clinical Drug Information

English Name	Research Code	Highest Development Stage	Company	Indication	Clinical Trial
IDL-2965	IDL-2965	Phase 2 Clinical	Indalo Therapeutics Inc	Idiopathic Pulmonary Fibrosis; Metabolic Dysfunction-Associated Steatotic Liver Disease	Details
Bexotegrast	PLN-74809	Phase 2 Clinical	Pliant Therapeutics Inc	Cholangitis, Sclerosing; Coronavirus Disease 2019 (COVID-19); Idiopathic Pulmonary Fibrosis; Respiratory Distress Syndrome, Adult	Details
Nesvategrast	SF-0166; OTT-166(OcuTerra Therapeutics)	Phase 2 Clinical	OcuTerra Therapeutics Inc, Scifluor Life Sciences Inc	Diabetic macular oedema; Diabetic Retinopathy; Macular Degeneration	Details
18F-αvβ6-Binding-Peptide	18F-αvβ6-BP	Phase 1 Clinical	National Cancer Institute, National Institutes Of Health	Breast Neoplasms; Colonic Neoplasms; Colorectal Neoplasms; Coronavirus Disease 2019 (COVID-19); Lung Neoplasms; Metastatic breast cancer; Pancreatic Neoplasms; Rectal Neoplasms	Details
[18F]FP-R01-MG	[18F]FP-R01-MG-F2; [18F]FP-R01-MG	Phase 1 Clinical	Chinese Academy Of Medical Science & Peking Union Medical College, Pliant Therapeutics Inc, Stanford University	Brain metastases; Carcinoma, Non-Small-Cell Lung; Cholangitis, Sclerosing; Coronavirus Disease 2019 (COVID-19); Idiopathic Pulmonary Fibrosis; Lung Neoplasms; Pancreatic Neoplasms	Details
Ga-68-Trivehexin	RAD-301	Phase 1 Clinical	Trimt GmbH	Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Endometrial Neoplasms; Esophageal Squamous Cell Carcinoma; Ovarian Neoplasms; Pancreatic Neoplasms; Uterine Cervical Neoplasms	Details

Customer Reviews

A***l2022-03-15
Biotinylated Human Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein, His,Avitag™&Tag Free (MALS verified)
Great communication from the Acro team--quickly received an email detailing the estimated delivery timeframe and asking if that timeframe was acceptable. Product was ready per the timeline provided by the Acro biosystems team and shipped. This was a new product for us (though we’ve used other acro biosystems products previously) and worked well for our intended use with Surface Plasmon Resonance (SPR). Thank you all!