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Home PageAll MoleculesLILRB4
LILRB4
LILRB4 Overview
| English Name | Leukocyte immunoglobulin-like receptor subfamily B member 4 | Approved Drugs | 0 |
| Drugs in Clinical Trials | 7 | Target Synonym | CD85k Antigen，Leukocyte immunoglobulin-like receptor 5，Immunoglobulin-like transcript 3，CD85k，CD85 antigen-like family member K，LIR-5，Monocyte inhibitory receptor HM18，ILT-3，Leucocyte Ig-Like Receptor B4，ILT3，LIR5，Leukocyte Immunoglobulin-Like Receptor， Subfamily B (With TM And ITIM Domains)， Member 4，HM18，Leukocyte Immunoglobulin Like Receptor B4 |
| Highest Development Stage | Phase 2 Clinical | ||
| English Name | Leukocyte immunoglobulin-like receptor subfamily B member 4 |
| Target Synonym | CD85k Antigen，Leukocyte immunoglobulin-like receptor 5，Immunoglobulin-like transcript 3，CD85k，CD85 antigen-like family member K，LIR-5，Monocyte inhibitory receptor HM18，ILT-3，Leucocyte Ig-Like Receptor B4，ILT3，LIR5，Leukocyte Immunoglobulin-Like Receptor， Subfamily B (With TM And ITIM Domains)， Member 4，HM18，Leukocyte Immunoglobulin Like Receptor B4 |
| Approved Drugs | 0 |
| Drugs in Clinical Trials | 7 |
| Highest Development Stage | Phase 2 Clinical |
LILRB4 Product List
- Product Category
Protein (11)
- Product Status
Launched (11)
- Species
Cynomolgus (2)Mouse (2)Human (7)
- Tag
Fc Tag (3)His Tag (4)His Tag & Avi Tag (2)Mouse IgG Fc Tag (1)Fc Tag & Avi Tag (1)
- Conjugate
Unconjugated (6)FITC Labeled (2)Biotin-labeled (3)
Total: 11
- 1
- 2
LILRB4 Background
Leukocyte immunoglobulin-like receptor subfamily B member 4 (LILRB4) is also known as CD85 antigen-like family member K (CD85K), Immunoglobulin-like transcript 3 (ILT-3), Leukocyte immunoglobulin-like receptor 5 (LIR-5), Monocyte inhibitory receptor HM18, which belongs to the leukocyte immunoglobulin-like receptor (LIR) family. LILRB4 / CD85K contains 2 Ig-like C2-type (immunoglobulin-like) domains. CD85K is detected in monocytes, macrophages, dendritic cells, lung, natural killer cells and B-cells. LILRB4 / CD85K is receptor for class I MHC antigens. CD85K recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles, involved in the down-regulation of the immune response and the development of tolerance. LILRB4 interferes with TNFRSF5-signaling and NF-kappa-B up-regulation and inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.
LILRB4 Synonyms
LILRB4,ILT3,LIR5,CD85K,HM18
Clinical Drug Information
| English Name | Research Code | Highest Development Stage | Company | Indication | Clinical Trial |
|---|---|---|---|---|---|
| MK-0482 | MK-0482 | Phase 2 Clinical | Merck Sharp & Dohme Corp | Carcinoma, Non-Small-Cell Lung; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Chronic; Neoplasms; Sarcoma; Squamous Cell Carcinoma of Head and Neck | Details |
| IO-202 | IO-202 | Phase 1 Clinical | Yiming Biomedical Technology (Hangzhou) Co Ltd | Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Chronic; Solid tumours | Details |
| anti-ILT3 CAR T-cell therapy (Carbiogene Therapeutics) | Phase 1 Clinical | Carbiogene Therapeutics Co Ltd | Leukemia, Myeloid, Acute | Details | |
| YTS-104 | LILRB4 STAR-T; YTS-104 | Phase 1 Clinical | Beijing Qingyi Taike Pharmaceutical Technology Co Ltd, China Immunotech Co Ltd | Leukemia, Myeloid | Details |
| BND-35 | BND-35; BND35 | Phase 1 Clinical | Biond Biologics Ltd | Neoplasms; Solid tumours | Details |
| NGM-831 | NGM-831 | Phase 1 Clinical | NGM Biopharmaceuticals Inc | Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Cholangiocarcinoma; Colorectal Neoplasms; Esophageal Neoplasms; Melanoma; Mesothelioma; Ovarian Neoplasms; Pancreatic Neoplasms; Prostatic Neoplasms; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Uterine Cervical Neoplasms | Details |
| anti-ILT3 CAR-T Therapy(Carbiogene) | Phase 1 Clinical | Carbiogene Therapeutics Co Ltd | Leukemia, Myeloid, Acute | Details |
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