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Home PageAll MoleculesNeprilysin
Neprilysin
Neprilysin Overview
| English Name | Neprilysin | Approved Drugs | 3 |
| Drugs in Clinical Trials | 8 | Target Synonym | EC:3.4.24.11，EC 3.4.24，Atriopeptidase，NEP，SFE，Membrane Metallo-Endopeptidase (Neutral Endopeptidase， Enkephalinase， CALLA， CD10)，Membrane Metallo-Endopeptidase Variant 1，Membrane Metallo-Endopeptidase Variant 2，Neprilysin-390，Neprilysin-411，CD10 Antigen，EC 3.4.24.11，CMT2T，SCA43，EPN，MME，Enkephalinase，CALLA，Neutral endopeptidase，Common acute lymphocytic leukemia antigen，Neprilysin，CD10，Membrane Metalloendopeptidase，Neutral Endopeptidase 24.11，Skin fibroblast elastase |
| Highest Development Stage | Approved | ||
| English Name | Neprilysin |
| Target Synonym | EC:3.4.24.11，EC 3.4.24，Atriopeptidase，NEP，SFE，Membrane Metallo-Endopeptidase (Neutral Endopeptidase， Enkephalinase， CALLA， CD10)，Membrane Metallo-Endopeptidase Variant 1，Membrane Metallo-Endopeptidase Variant 2，Neprilysin-390，Neprilysin-411，CD10 Antigen，EC 3.4.24.11，CMT2T，SCA43，EPN，MME，Enkephalinase，CALLA，Neutral endopeptidase，Common acute lymphocytic leukemia antigen，Neprilysin，CD10，Membrane Metalloendopeptidase，Neutral Endopeptidase 24.11，Skin fibroblast elastase |
| Approved Drugs | 3 |
| Drugs in Clinical Trials | 8 |
| Highest Development Stage | Approved |
Neprilysin Product List
- Product Category
Protein (3)
- Product Status
Launched (3)
- Species
Human (3)
- Tag
Fc Tag (1)Tag Free (1)His Tag (1)
- Conjugate
Unconjugated (3)
| Cat. No. | Species | Host | Product Description | Structure | Purity | Feature |
|---|---|---|---|---|---|---|
MME-H521b |  Human | HEK293 | Human Neprilysin / MME / CD10 Protein, Tag Free (active enzyme) |  |  | |
MME-H5243 | Human | HEK293 | Human Neprilysin / MME / CD10 Protein, His Tag (active enzyme, MALS verified) |  | | |
MME-H526a | Human | HEK293 | Human Neprilysin / MME / CD10 Protein, Fc Tag |  | |
Total: 3
- 1
Neprilysin Background
CD10 is an endopeptidase that degrades various bioactive peptides in the extracellular matrix. In addition to enzymatic degradation, it affects multiple intracellular signal transduction pathways. CD10 expression has been extensively studied in human epithelial cancers of numerous organs and sites. CD10 expression pattern depended on the histotypes of thyroid lesions. When possible metastatic tumours and non-epithelial tumours are excluded, high CD10 expression may be useful in determining whether a primary thyroid carcinoma includes an anaplastic component.
Neprilysin Synonyms
MME,CALLA,CD10,DKFZp686O16152,MGC126681,MGC126707,NEP,SFE,Neprilysin
Clinical Drug Information
| English Name | Research Code | Highest Development Stage | Company | Indication | Clinical Trial |
|---|---|---|---|---|---|
| Dexecadotril | Phase 3 Clinical | Bioprojet Pharma | Gastrointestinal Diseases | Details | |
| Sacubitril/Valsartan (Chong Kun Dang Pharmaceutical) | CKD-202A | Phase 3 Clinical | Chong Kun Dang Pharmaceutical Corp | Essential Hypertension | Details |
| QR-12000 | QR-12000 | Phase 3 Clinical | Wuhan Createrna Science and Technology Co Ltd | Essential Hypertension; Hypertension | Details |
| Debio-0827 | PL-37; Debio-0827 | Phase 2 Clinical | Pharmaleads | Pain | Details |
| Sacubitril | AHU-377 | Phase 2 Clinical | Novartis Pharma Ag | Cardiomyopathy, Hypertrophic; Cardiovascular Diseases; Diabetes Mellitus; Essential Hypertension; Heart Failure; Hypertension; Insulin Resistance; Metabolic Diseases | Details |
| Anti-CD10 CAR T-cell therapy (Zhujiang Hospital/Nanfang Hospital) | Phase 1 Clinical | Southern Medical University Zhujing Hospital | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma | Details | |
| Sacubitril Valsartan Sodium Extended-Relesae Tablets(Taizhou Overseas Pharma) | Phase 1 Clinical | Taizhou Overseas Pharmaceuticals Co Ltd | Heart Failure | Details | |
| Sacubitril/Allisartan Isoproxil/Amlodipine Besylate | Phase 1 Clinical | Shenzhen Salubris Pharmaceuticals Co Ltd | Essential Hypertension | Details |
Marketed Drug Information
| English Name | Research Code | Highest Development Stage | Company | Earliest Brand Name | Earliest Approval Country | Earliest Indication | Earliest Approval Company | Earliest Approval Date | Indication | Clinical Trial |
|---|---|---|---|---|---|---|---|---|---|---|
| Sacubitril/Allisartan Isoproxil | AHU-377/EXP3174; S-086 | Approved | Shenzhen Salubris Pharmaceuticals Co Ltd | 信超妥 | Mainland China | Essential Hypertension | Shenzhen Salubris Pharmaceuticals Co Ltd | 2025-05-20 | Essential Hypertension; Heart Failure; Hypertension | Details |
| Sacubitril/Valsartan Sodium Hydrate | LCZ-696; LCZ-696A | Approved | Novartis Pharma Ag | ENTRESTO SPRINKLE, Enresuto, Enrest, Entresto, Neparvis, 诺欣妥, 科畅欣 | United States | Heart Failure | Novartis Pharmaceuticals Corp | 2015-07-07 | Breast Neoplasms; Cardiomyopathy, Hypertrophic; Cardiovascular Diseases; Coronavirus Disease 2019 (COVID-19); Erectile Dysfunction; Essential Hypertension; Heart Defects, Congenital; Heart Diseases; Heart Failure; Heart Failure, Diastolic; Heart Failure, Systolic; Hepatic Insufficiency; Hypertension; Lymphoma; Myocardial Infarction; Obesity; Peripheral Arterial Disease; Postmyocardial Infarction Syndrome; Renal Insufficiency; Renal Insufficiency, Chronic; Ventricular Dysfunction, Left | Details |
| Racecadotril | Tiorfan; Hidrasec | Approved | Bioprojet Pharma | France | Diarrhea | Bioprojet Pharma | 1993-03-23 | Diarrhea; Diarrhea, Infantile; Sepsis | Details |
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