RIPK2

Receptor-interacting protein kinase 2 (RIPK2) is a crucial downstream signaling node for NOD1 and NOD2 intracellular pattern recognition receptors. Upon activation, RIPK2 drives NF-κB and MAPK pathways, triggering robust pro-inflammatory cytokine production. Dysregulation of RIPK2 is strongly linked to autoimmune and inflammatory disorders, particularly Crohn's disease, making it a highly attractive target for novel kinase inhibitors and PROTAC degraders.