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SDF-1

SDF-1 Overview

English NameC-X-C motif chemokine ligand 12Approved Drugs0
Drugs in Clinical Trials5Target SynonymPre-B Cell Growth-Stimulating Factor，SDF1B，C-X-C Motif Chemokine Ligand 12，SDF1，SDF-1，Chemokine (C-X-C Motif) Ligand 12，Stromal Cell-Derived Factor 1，CXCL12，HSDF-1，SCYB12，C-X-C Motif Chemokine 12，IRH，TLSF，Chemokine CXCL12，TLSF-A，TLSF-B，SDF-1b，SDF-1a，Intercrine Reduced In Hepatomas，TPAR1，PBSF，HIRH，SDF1A
Highest Development StagePhase 2 Clinical
English NameC-X-C motif chemokine ligand 12
Target SynonymPre-B Cell Growth-Stimulating Factor，SDF1B，C-X-C Motif Chemokine Ligand 12，SDF1，SDF-1，Chemokine (C-X-C Motif) Ligand 12，Stromal Cell-Derived Factor 1，CXCL12，HSDF-1，SCYB12，C-X-C Motif Chemokine 12，IRH，TLSF，Chemokine CXCL12，TLSF-A，TLSF-B，SDF-1b，SDF-1a，Intercrine Reduced In Hepatomas，TPAR1，PBSF，HIRH，SDF1A
Approved Drugs0
Drugs in Clinical Trials5
Highest Development StagePhase 2 Clinical

SDF-1 Product List

  • Product Category

    Protein (3)

  • Product Status

    Launched (3)

  • Species

    Human (3)

  • Tag

    His Tag (1)Tag Free (2)

  • Conjugate

    Unconjugated (3)

Cat. No.SpeciesHostProduct DescriptionStructurePurityFeatureOrder Now
SD1-H5115
Human
E. coli
Human SDF-1 / CXCL12 Protein, premium grade
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SD1-H5116
Human
E. coli
Human SDF-1 / CXCL12 Protein, Research Grade
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SD1-H5143
Human
E. coli
Human SDF-1 / CXCL12 Protein, His Tag (HPLC & SPR verified)
 Add to Cart
Total: 3
  • 1

SDF-1 Background

Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation. Stimulates the proliferation of bone marrow-derived B-cell progenitors in the presence of IL7 as well as growth of stromal cell-dependent pre-B-cells

SDF-1 Synonyms

SDF-1,CXCL12,hSDF-1,IRH,hIRH,PBSF,SDF1,SDF1A,SDF1B

Clinical Drug Information

English NameResearch CodeHighest Development StageCompanyIndicationClinical Trial
Olaptesed PegolNOX-A12Phase 2 ClinicalNoxxon PharmaColorectal Neoplasms; Glioblastoma; Hematopoietic stem cell transplantation (HSCT); Leukemia, Lymphocytic, Chronic, B-Cell; Multiple Myeloma; Pancreatic Neoplasms
Details
PTX-9908PTX-9908Phase 2 ClinicalPertinax TherapeuticsCarcinoma, Hepatocellular
Details
JVS-100JVS-100; SRX-100; ACRX-100; GP-51801; GP51801Phase 1 ClinicalCleveland ClinicHeart Failure; Ischemia; Peripheral Arterial Disease; Surgical Wound
Details
CK-0804CK-08041; CK-0804Phase 1 ClinicalCellenkos IncPrimary Myelofibrosis
Details
MyoCell SDF-1MyoCell SDF-1ClinicalU.S. Stem CellHeart Failure
Details
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  • Clinical Drug Information
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