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Siglec-10
Siglec-10 Overview
| English Name | Sialic acid-binding Ig-like lectin 10 | Approved Drugs | 0 |
| Drugs in Clinical Trials | 3 | Target Synonym | UNQ477/PRO940，SIGLEC10，Sialic Acid Binding Ig Like Lectin 10，Sialic Acid Binding Ig-Like Lectin 10 Ig-Like Lectin 7，Siglec-Like Protein 2，Siglec-Like Gene 2，SLG2，Sialic Acid-Binding Ig-Like Lectin 10，Sialic Acid Binding Ig-Like Lectin 10，Siglec-10，PRO940，MGC126774 |
| Highest Development Stage | Phase 3 Clinical | ||
| English Name | Sialic acid-binding Ig-like lectin 10 |
| Target Synonym | UNQ477/PRO940，SIGLEC10，Sialic Acid Binding Ig Like Lectin 10，Sialic Acid Binding Ig-Like Lectin 10 Ig-Like Lectin 7，Siglec-Like Protein 2，Siglec-Like Gene 2，SLG2，Sialic Acid-Binding Ig-Like Lectin 10，Sialic Acid Binding Ig-Like Lectin 10，Siglec-10，PRO940，MGC126774 |
| Approved Drugs | 0 |
| Drugs in Clinical Trials | 3 |
| Highest Development Stage | Phase 3 Clinical |
Siglec-10 Product List
- Product Category
Protein (10)
- Product Status
Launched (10)
- Species
Human (7)Mouse (1)Cynomolgus (2)
- Tag
Mouse IgG Fc Tag (1)Fc Tag (2)His Tag (4)Fc Tag & Avi Tag (1)His Tag & Avi Tag (2)
- Conjugate
Unconjugated (6)Biotin-labeled (3)PE Labeled (1)
Add to Cart
Total: 10
- 1
Siglec-10 Background
The siglecs (sialic acid-binding Ig-like lectins) are a distinct subset of the Ig superfamily with adhesion-molecule-like structure. We describe here a novel member of the siglec protein family that shares a similar structure including five Ig-like domains, a transmembrane domain, and a cytoplasmic tail containing two ITIM-signaling motifs. Siglec-10 was identified through database mining of an asthmatic eosinophil EST library. The Siglec-10-VAP-1 interaction seems to mediate lymphocyte adhesion to endothelium and has the potential to modify the inflammatory microenvironment via the enzymatic end products.
Siglec-10 Synonyms
SIGLEC10,MGC126774,PRO940,Siglec10,SLG2
Clinical Drug Information
| English Name | Research Code | Highest Development Stage | Company | Indication | Clinical Trial |
|---|---|---|---|---|---|
| Efprezimod alfa | CD24-Fc; HAS-CD24; CD24-Fc-IgG; MK-7110; MK7110 | Phase 3 Clinical | Oncoimmune Inc | Coronavirus Disease 2019 (COVID-19); Dyslipidemias; Graft vs Host Disease; Hematopoietic stem cell transplantation (HSCT); HIV Infections; Leukemia; Leukemia, Myeloid, Acute; Melanoma; Myelodysplastic Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Solid tumours | Details |
| EXO-CD24 | Phase 2 Clinical | Nano24med, Tel-Aviv Sourasky Medical Center | Coronavirus Disease 2019 (COVID-19); Respiratory Distress Syndrome, Adult | Details | |
| ONC-841 | ONC-841 | Phase 1 Clinical | AcroImmune Group | Alzheimer Disease; Neoplasms; Solid tumours | Details |
Product Reviews
V***w2023-03-17
0People LikeThe timely fashion that this protein was delivered has helped us greatly. Knowing how reliable and effective Acro Biosystems is with their product delivery is refreshing. Having access to a quick vendor has helped push along studies. The user interface and accessibility of Acro’s website makes it easy to find exactly what we need when we need it. Definitely will continue to purchase from Acro.
A***r2022-10-20 0People LikeWe have been using this Human Siglec-10 Protein, His Tag as a capture for an electrochemiluminescent immunoassay. The performance of the assay was very consistent; the background was low and signal-to-noise ratio was very good, so we were able to get great sensitivity. We’ve ordered from ACRO Biosystems several times for this assay and every time shipments are very consistent and timely, and the reagent is always in stock. They are also very responsive whenever we have product questions or documentation questions regarding certain lots.- C***e2022-09-23 0People LikeService with Acro and their customer support is as quick as they are helpful. Product was needed as soon as possible for a study and they helped us out in getting the product shipped out and delivered us within 2 days of purchasing. Customer support personal are as friendly as they are insightful. Never have they disappointed when purchasing any of their products.
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