TOP2A

TOP2A

TOP2A Overview

Molecule Name
Topoisomerase (DNA) II alpha
Synonyms
TOP2A,TOP2,DNA topoisomerase 2-alpha,DNA topoisomerase II,alpha isozyme
Drug Development Progress
Drugs in Clinical Trials1
Approved Drugs1
Highest Development StageApproved
Target Synonym
EC:5.6.2.2,EC 5.6.2.2,TOP2A,DNA topoisomerase 2-alpha,DNA topoisomerase II, alpha isozyme,DNA Topoisomerase II Alpha,Topoisomerase (DNA) II Alpha 170kDa,TOP2,DNA Topoisomerase (ATP-Hydrolyzing),DNA Topoisomerase II, 170 KD,EC 5.99.1.3,TP2A,DNA Gyrase
Background
DNA topoisomerase 2-alpha (TOP2A) is also known as DNA topoisomerase II, alpha isozyme and TOP2. It is a topoisomerase which control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes. May play a role in regulating the period length of ARNTL/BMAL1 transcriptional oscillation. Also it is the targets of anti-cancer drugs that cause treatment-related leukemias with balanced translocations.

TOP2A Product List

Species
  • Human(1)
Tag
  • Tag Free(1)
Host
  • E. coli(1)
Conjugate
  • Unconjugated(1)
Grade
  • RUO(1)
Low Endotoxin
  • No(1)
MoleculeCat. No.Product NameSpeciesHostStructurePurityActivitySize&Price
TOP2A
Human TOP2A / TOP2 Protein, Tag Free
Human
E. coli
SDS-PAGE

$310.00

20ug
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Clinical Drug Information

English NameResearch CodeHighest Development StageCompanyIndicationClinical Trial
Novobiocin SodiumPhase 1 Clinical
Bacterial Infections; Neoplasms; Solid tumours
Details

Marketed Drug Information

English NameResearch CodeHighest Development StageCompanyFirst Brand NameFirst Approved CountryFirst IndicationFirst Approved CompanyFirst Approved DateIndicationClinical Trial
Etoposide phosphateBMY-40481ApprovedBristol-Myers Squibb CompanyEtopophosUnited StatesLymphoma, Non-Hodgkin; Multiple Myeloma; Testicular Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Hodgkin Disease; Small Cell Lung CarcinomaCheplapharm Arzneimittel Gmbh1996-05-17
Adrenocortical Carcinoma; Breast Neoplasms; Burkitt Lymphoma; Carcinoma, Non-Small-Cell Lung; CNS Embryonal Tumor; Germinoma; Hodgkin Disease; Kidney Neoplasms; Leukemia; Lung Neoplasms; Lymphoma; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Large-Cell, Immunoblastic; Lymphoma, Non-Hodgkin; Multiple Myeloma; Myelodysplastic Syndromes; Myelodysplastic-Myeloproliferative Diseases; Myeloproliferative Disorders; Neoplasm Metastasis; Neoplasms; Neoplasms, Germ Cell and Embryonal; Neoplasms, Gonadal Tissue; Neoplasms, Plasma Cell; Neuroblastoma; Neutropenia; Ovarian Neoplasms; Plasmacytoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sarcoma; Sarcoma, Ewing; Small Cell Lung Carcinoma; Solid tumours; Testicular Neoplasms; Thrombocytopenia; Uterine Cervical Neoplasms
Details
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