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Integrin alpha V beta 6

Brief Information

Name:Integrin alpha-V/beta-6
Target Synonym:
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:4
Lastest Research Phase:Phase 2 Clinical

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Part of Bioactivity data

IT6-H52E1-ELISA
Human ITGAV&ITGB6 Heterodimer Protein, His Tag&Tag FreeHuman ITGAV&ITGB6 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT6-H52E1) ELISA bioactivity

Immobilized Human ITGAV&ITGB6 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT6-H52E1) at 5 μg/mL (100 μL/well) can bind Biotinylated Human Latent TGF-Beta 1, His,Avitag (Cat. No. TG1-H82Qb) with a linear range of 0.5-4 ng/mL (QC tested).

IT6-H82E4-ELISA
Biotinylated Human ITGAV&ITGB6 Heterodimer Protein, His,Avitag&Tag FreeBiotinylated Human ITGAV&ITGB6 Heterodimer Protein, His,Avitag&Tag Free (Cat. No. IT6-H82E4) ELISA bioactivity

Immobilized Human TGFB1, His Tag (Cat. No. TG1-H524x) at 5 μg/mL (100 μL/well) can bind Biotinylated Human ITGAV&ITGB6 Heterodimer Protein, His,Avitag&Tag Free (Cat. No. IT6-H82E4) with a linear range of 2-10 ng/mL (QC tested).

Synonym Name

Integrin alpha V beta 6,ITGAV&ITGB6,ITGAV&B6

Background

Integrin alpha V beta 6 is a heterodimer of beta-6 associating with alpha-V. Integrin alpha-V beta-6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. Also, Integrin alpha-V beta-6 acts as a receptor for coxsackievirus A9 and coxsackievirus B1 as well as herpes simplex virus-1/HHV-1. Furthermore, it binds the TGF-beta latency

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
[18F]FP-R01-MG [18F]FP-R01-MG; [18F]FP-R01-MG-F2 Phase 1 Clinical Pliant Therapeutics, Stanford University, Chinese Academy Of Medical Science & Peking Union Medical College Idiopathic Pulmonary Fibrosis; Pancreatic Neoplasms Details
IDL-2965 IDL-2965 Phase 2 Clinical Indalo Therapeutics Non-alcoholic Fatty Liver Disease; Idiopathic Pulmonary Fibrosis Details
PLN-74809 PLN-74809 Phase 2 Clinical Pliant Therapeutics Idiopathic Pulmonary Fibrosis; Respiratory Distress Syndrome, Adult; Cholangitis, Sclerosing Details

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