Aneuro | Neural Factors

NGF is a type of protein that can accelerate the growth, development, differentiation and rapid maturation of central and peripheral neurons. As the earliest discovered and most thoroughly studied neurotrophic factor, it plays an important role in regulating the development, differentiation, growth, regeneration and expression of functional properties of central and peripheral neurons. NGF contains three subunits, α, β, and γ, and the active region is the β subunit.

NT-3 can maintain the survival of neural stem cells, promote their proliferation and differentiation, and maintain the survival of sensory neurons and sympathetic neurons in the peripheral nervous system and motor neurons in the central nervous system.

NT-4 is the fourth member of the neuron factor family, which plays an important role in promoting the growth, development, differentiation and maturation of neurons. It can maintain the survival of neurons, and promote repair and regeneration after neuron damage, mediate neuro-immunity-endocrine, regulate synaptic plasticity, promote the formation of neuromuscular junctions and induce collateral sprouting in normal motor neurons.

GDNF is a neural factor with unique neurotrophic properties. It can promote the survival of different neuronal subsets in the development of central and peripheral nervous systems at different stages and support the survival of midbrain dopaminergic neurons in vitro. Moreover, GDNF has been validated in various animal models of Parkinson's disease to improve conditions such as bradykinesia, stiffness and postural instability.

Midkine (MDK), also known as neurite outgrowth promoting factor-2, is a heparin-binding growth factor discovered in 1988, which has the functions of cell proliferation, cell migration, angiogenesis and fibrinolysis.