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Your Position: Home > Solid Tumor CAR Targets

Solid Tumor CAR Targets

Solid Tumor CAR Targets
Background
Adoptive cell therapies using genetically modified T cells have been clinically effective against hematological malignancies. However, targeting solid tumors has proven to be challenging. With advancements in tumor biology and immunology, scientists have developed various strategies to overcome these obstacles, potentially leading to a significant breakthrough in combating solid tumors.

ACROBiosystems has developed a series of solid tumor-related target proteins,including MSLN, GPC3, FAP, HER2, and EGFR vIII, covering different species and fluorescent labeling types to support cell therapy in solid tumors. These products can be used for immune screening, CAR detection and PK study to accelerate your cell therapy development research.
Nature reviews. Drug discovery vol. 20,7 (2021): 531-550.

Nature reviews. Drug discovery vol. 20,7 (2021): 531-550.

Product Features

More than 30 + solid tumor targets

Various species including human, mouse, monkey, rabbit, etc

High bioactivity verified by FACS/ELISA/SPR

Alexa Fluor 488/555/647, PE, APC, FITC-labels available

Some products have been filed with FDA DMF to support your IND, NDA and BLA

Hot Targets
MSLN
  1. > Mesothelin,MSLN

  2. > Highly expressed in mesothelial tumors, ovarian cancer and pancreatic cancer

  3. > Mesothelin abnormal expression by activating P13K, ERK and MAPK signaling pathways cause cancer cell proliferation, invasion and metastasis.

GPC3
  1. > Glypican 3,GPC3

  2. > Associated with hepatocellular carcinoma, ovarian carcinoma, and squamous cell carcinoma

  3. > Interacts with various growth factors and signaling molecules in the tumor microenvironment that affect tumor cell proliferation, migration, invasion and development process.

HER2
  1. > Human epidermal growth factor receptor 2,HER2

  2. > Related to breast cancer, gastric cancer, lung cancer and non-small cell lung cancer

  3. > Promotes cell division and the secretion of proteolytic enzymes, thereby promoting tumor invasion and metastasis.

FAP
  1. > Fibroblast activation protein,FAP

  2. > Selectively high expression on the surface of cancer associated fibroblasts (CAF)

  3. > Degrades tumor stroma and promote cancer cell invasion and metastasis in a variety of tumors.

Data
High purity
Human Mesothelin has high purity  verified by SEC-MALS

The purity of Human Mesothelin (296-580), His Tag, low endotoxin (Cat. No. MSN-H522a) is more than 90% and the molecular weight of this protein is around 32-47 kDa verified by SEC-MALS.

High bioactivity
>High bioactivity verified by ELISA for early antibody screening
Biotinylated Human GPC3  has high bioactivity verified by ELISA

Immobilized Monoclonal Anti-Human GPC3 Antibody, Human IgG1 at 2 μg/mL (100 μL/well) can bind Biotinylated Human Glypican 3, His, Avitag (Cat. No. GP3-H82E5) with a linear range of 0.2-3 ng/mL (QC tested).

Human Her2 has high bioactivity verified by ELISA

Immobilized Human Her2, His Tag (Cat. No. HE2-H5225) at 0.05 μg/mL (100 μL/well) can bind Trastuzumab with a linear range of 0.2-3 ng/mL (Routinely tested).


>High bioactivity verified by FACS and suitable for CAR detection and PK study
Alexa Fluor 488-Labeled Human Mesothelin(Cat. No. MSN-HA2H9)
Alexa Fluor 488-Labeled Human MSLN has high bioactivity verified by FACS

5e5 of anti-MSLN CAR-293 cells were stained with 100 μL of 3 μg/mL of AF488-Labeled Human Mesothelin (296-580), His Tag (Cat. No. MSN-HA2H9) and negative control protein respectively (Fig. C and B), and non-transfected 293 cells were used as a control (Fig. A). AF488 signal was used to evaluate the binding activity (QC tested).

APC-Labeled Human Her2 Protein(Cat. No. HE2-HA2H7)
APC-Labeled Human Her2 has high bioactivity verified by FACS

5e5 of anti-Her2 CAR-293 cells were stained with 100 μL of 1:25 dilution (4 μL stock solution in 100 μL FACS buffer) of APC-Labeled Human Her2, His Tag (Cat. No. HE2-HA2H7) and negative control protein respectively. APC signal was used to evaluate the binding activity (QC tested).

PE-Labeled Human GPC3 Protein(Cat. No. GP3-HP2E3)
PE-Labeled Human GPC3 has high bioactivity verified by FACS

5e5 of anti-GPC3 CAR-293 cells were stained with 100 μL of 1:25 dilution (4 μL stock solution in 100 μL FACS buffer) of PE-Labeled Human Glypican 3, His Tag (Cat. No. GP3-HP2E3) and negative control protein respectively. PE signal was used to evaluate the binding activity (QC tested).

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