0
There is no goods in the shopping cart !
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 0-9
Your Position: Home > SARS-CoV-2 Related Products

SARS-CoV-2 Related Products

SARS-CoV-2 Proteins and Inhibitor Screening Kit

The pandemic caused by SARS-CoV-2 is a public health emergency of international concern. Data from WHO showed that there were more than 7.38 million confirmed cases globally by June 12, 2020. ACROBiosystems has been keeping a close eye on the development of the epidemic situation and accelerating the development of SARS-COV-2 antigen proteins, antibodies, kits and other related products to facilitate the development of serologic tests,therapeutic antibodies and vaccines.

ACROBiosystems has developed more than 60 products related to SARS-CoV-2, including recombinant proteins, antibodies, kits, beads and so on covering the critical targets of SARS-CoV-2. ACROBiosystems has provided core proteins and antibody materials for several in vitro diagnostic companies to support the development of SARS-COV-2 diagnostic kits.

Recombinant Proteins

SARS-CoV-2 is an enveloped positive-stranded RNA virus that consists of four structural proteins including spike (S) glycoprotein, envelope (E) protein, membrane (M) protein, and nucleocapsid (N) protein. Spike glycoprotein is the most important surface protein of SARS-CoV-2, which can mediate the virus entry into human respiratory epithelial cells by interacting with cell surface receptor angiotensin-converting enzyme 2 (ACE2). S, S1 and S RBD proteins are important targets in the development of SARS-COV-2 therapeutics and vaccines. The quality and application of SARS-COV-2 S, S1, S RBD and human ACE2 and other proteins are the key to the development of antiviral drugs.

ACROBiosystems has developed nearly 50 kinds of high-quality proteins related to SARS-CoV-2 based on HEK293 human cell expression platform. The natural bioactivities and affinities were verified by ELISA/MALS/SPR/BLI, etc.

Antigens for COVID-19 diagnostics
  1. > Customized formulation and bulk order available

  2. > High purity and batch-to-batch consistency

  3. > Validated bioactivity

Trimer S protein
(Exclusive)
  1. > Molecular weight and polymer structure verified by SEC-MALS

  2. > Bioactivity verified

  3. > Biologically function well

Biotinylated proteins
(Featured)
  1. > Unique Avitag™ technology employed

  2. > Uniform labeling, and natural activity

  3. > High purity and batch-to-batch consistency

Antigenic proteins
  1. > Authentic conformation and complete glycosylation

  2. > High purity and batch-to-batch consistency

  3. > Bioactivities verified

Associated host
ACE2 proteins
  1. > High purity and batch-to-batch consistency

  2. > High activity and affinity

  3. > Multiple species

Assay Data

Fig.1 The purity of SARS-CoV-2 S protein (R683A, R685A), His Tag, active trimer (Cat. No. SPN-C52H8) was more than 80% and around 550-660 kDa verified by SEC-MALS.

Fig.2 Human ACE2, Fc Tag (Cat. No.AC2-H5257) Captured on CM5 chip via anti-human IgG Fc antibodies surface can bind SARS-CoV-2 S protein (R683A, R685A), His Tag, active trimer (Cat. No.SPN-C52H8) with an affinity constant of 35.3 nM as determined in a SPR assay (Biacore 8K).

Product list

MoleculeCat. No.SpeciesHostProduct DescriptionOrder/Preorder
ACE2AC2-H82E6HumanHEK293Biotinylated Human ACE2 / ACEH Protein, His,Avitag™ (MALS verified)

Order

AC2-H82F9HumanHEK293Biotinylated Human ACE2 / ACEH Protein, Fc,Avitag™

Order

AC2-H5257HumanHEK293Human ACE2 / ACEH Protein, Fc Tag (MALS verified)

Order

AC2-C52H7CynomolgusHEK293Cynomolgus ACE2 / ACEH Protein, His Tag

Order

AC2-H52H8HumanHEK293Human ACE2 / ACEH Protein, His Tag (MALS verified)

Order

AC2-R5246RatHEK293Rat ACE2 / ACEH Protein, His Tag (MALS verified)

Order

AC2-M5248MouseHEK293Mouse ACE2 / ACEH Protein, His Tag (MALS verified)

Order

AC2-P5248Paguma larvataHEK293Paguma larvata ACE2 / ACEH Protein, His Tag

Order

S proteinSPN-C52H8SARS-CoV-2HEK293SARS-CoV-2 (COVID-19)  S protein (R683A, R685A) , His Tag, active trimer (MALS verified)

Order

SPN-S52H5SARSHEK293SARS S protein (R667A), His Tag

Order

S1 proteinS1N-C52H3SARS-CoV-2HEK293SARS-CoV-2 (COVID-19) S1 protein, His Tag

Order

S1N-C82E8SARS-CoV-2HEK293Biotinylated SARS-CoV-2 (COVID-19) S1 protein, His,Avitag™ (MALS verified)

Order

S1N-S52H5SARSHEK293SARS S1 protein, His Tag (MALS verified)

Order

S1N-C52H4SARS-CoV-2HEK293SARS-CoV-2 (COVID-19) S1 protein, His Tag (MALS verified)

Order

S1N-C5255SARS-CoV-2HEK293SARS-CoV-2 (COVID-19) S1 protein, Fc Tag

Order

S1N-C5257SARS-CoV-2HEK293SARS-CoV-2 (COVID-19) S1 protein, Mouse IgG2a Fc Tag

Order

S1N-C5256SARS-CoV-2HEK293SARS-CoV-2 (COVID-19) S1 protein (D614G), His Tag

Order

S2 proteinS2N-C52H5SARS-CoV-2HEK293SARS-CoV-2 (COVID-19) S2 protein, His Tag

Order

S protein RBDSPD-C82E9SARS-CoV-2HEK293Biotinylated SARS-CoV-2 (COVID-19) S protein RBD, His,Avitag™ (MALS verified)

Order

SPD-C5255SARS-CoV-2HEK293SARS-CoV-2 (COVID-19) S protein RBD, Fc Tag (MALS verified)

Order

SPD-S52H6SARSHEK293SARS S protein RBD, His Tag (MALS verified)

Order

SPD-C52H3SARS-CoV-2HEK293SARS-CoV-2 (COVID-19) S protein RBD, His Tag (MALS verified)

Order

SPD-C5259SARS-CoV-2HEK293SARS-CoV-2 (COVID-19) S protein RBD, Mouse IgG2a Fc Tag

Order

SPD-S52H4SARS-CoV-2HEK293SARS-CoV-2 (COVID-19) S protein RBD (V367F), His Tag

Order

SPD-S52H5SARS-CoV-2HEK293SARS-CoV-2 (COVID-19) S protein RBD (N354D), His Tag

Order

SPD-S52H7SARS-CoV-2HEK293SARS-CoV-2 (COVID-19) S protein RBD (W436R), His Tag

Order

SPD-S52H8SARS-CoV-2HEK293SARS-CoV-2 (COVID-19) S protein RBD (R408I), His Tag

Order

SPD-S52H3SARS-CoV-2HEK293SARS-CoV-2 (COVID-19) S protein RBD (N354D, D364Y), His Tag

Order

SPD-C52H4SARS-CoV-2HEK293SARS-CoV-2 (COVID-19) S protein RBD (G476S), His Tag

Order

SPD-C52H5SARS-CoV-2HEK293SARS-CoV-2 (COVID-19) S protein RBD (V483A), His Tag

Order

S1 protein CTDS1D-C52H3SARS-CoV-2HEK293SARS-CoV-2 (COVID-19) S1 protein CTD, His Tag

Order

Nucleocapsid proteinNUN-C51H9SARS-CoV-2E.coliSARS-CoV-2 (COVID-19) Nucleocapsid protein, His Tag

Order

NUN-C5227SARS-CoV-2HEK293SARS-CoV-2 (COVID-19) Nucleocapsid protein, His Tag

Order

NUN-C81Q6SARS-CoV-2E.coliBiotinylated SARS-CoV-2 (COVID-19) Nucleocapsid protein, His,Avitag™

Order

Envelope proteinENN-C5128SARS-CoV-2E.coliSARS-CoV-2 (COVID-19) Envelope protein, GST,His Tag

Order

Papain-like ProteasePAE-C5148SARS-CoV-2E.coliSARS-CoV-2 (COVID-19) Papain-like Protease Protein, His Tag

Order

NSP1NS1-C51H7SARS-CoV-2E.coliSARS-CoV-2 (COVID-19) NSP1 Protein, His Tag

Order

NSP7NS7-C51H6SARS-CoV-2E.coliSARS-CoV-2 (COVID-19) NSP7 Protein, His Tag

Order

NSP8NS8-C5149SARS-CoV-2E.coliSARS-CoV-2 (COVID-19) NSP8 Protein, His Tag

Order

NSP7 & NSP8NS8-C5125SARS-CoV-2E.coliSARS-CoV-2 (COVID-19) NSP7&NSP8 Protein, His Tag

Order

NSP16 & NSP10NS0-C51W3SARS-CoV-2E.coliSARS-CoV-2 (COVID-19) NSP16&NSP10 Heterodimer Protein, His Tag&Twin Strep Tag

Order

S protein RBDSPD-M52H6MERSHEK293MERS S protein RBD, His Tag

Preorder

S1 proteinSIN-V52H3HCoV-NL63HEK293HCoV-NL63 S1 protein, His Tag

Preorder

Expected launch date: Jul. 23

SIN-V52H4HCoV-229EHEK293HCoV-229E S1 protein, His Tag

Preorder

Expected launch date: Jul. 23

SIN-V52H5HCoV-OC43HEK293HCoV-OC43 S1 protein, His Tag

Preorder

Expected launch date: Jul. 23

SIN-V52H6HCoV-HKU1(isolate N5)HEK293HCoV-HKU1(isolate N5) S1 protein, His Tag

Preorder

S1N-C82E3SARS-CoV-2HEK293SARS-CoV-2 (COVID-19) S1 protein (D614G), His,Avitag™

Preorder

Expected launch date: Aug. 6

S1 protein NTDS1D-C52H6SARS-CoV-2HEK293SARS-CoV-2 (COVID-19) S1 protein NTD, His Tag

Preorder

Expected launch date: Jul. 21

Nucleocapsid proteinNUN-V52H3HCoV-OC43HEK293HCoV-OC43 Nucleocapsid protein, His Tag

Preorder

NUN-V52H4HCoV-HKU1(isolate N5)HEK293HCoV-HKU1(isolate N5) Nucleocapsid protein, His Tag

Preorder

NUN-V52H6HCoV-NL63HEK293HCoV-NL63 Nucleocapsid protein, His Tag

Preorder

NUN-V52H8HCoV-229EHEK293HCoV-229E Nucleocapsid protein, His Tag

Preorder

NUN-M52H5MERSHEK293MERS Nucleocapsid protein, His Tag

Preorder

Antibodies

ACROBiosystems has developed human-derived anti-SARS-CoV-2 S protein RBD neutralizing antibody and Nucleocapsid antibody which are isolated from the serum of convalescent infect patients. The antibodies are of high purity and specificity, can be used as a control to develop various assays such as antibody titer assay, pseudovirus experiment and development of diagnostics kits, etc.

Assay Data

Fig.3 Neutralizing titer of Anti-SARS-CoV-2 Neutralizing Antibody, Human IgG1 (Cat. No. SAD-S35) measured by Anti-SARS-CoV-2 neutralizing antibody titer serologic assay kit (Cat. No. TAS-K003) in different concentrations of human serum (CV < 30%).

Product list

MoleculeCat. No.SpeciesProduct DescriptionOrder/Preorder
S protein RBDSAD-S35HumanAnti-SARS-CoV-2 neutralizing antibody, Human IgG1

Order

S1 protein
Antibody Pair
S1N-M122MouseAnti-SARS-CoV-2 Spike S1 Antibody, Chimeric MAb

Order

S1N-M130MouseAnti-SARS-CoV-2 Spike S1 Antibody, Chimeric MAb

Order

Nucleocapsid proteinNUN-S41HumanAnti-SARS-CoV-2 Nucleocapsid Antibody, Human IgG1

Order

Nucleocapsid protein
Antibody Pair
NUN-S46MouseAnti-SARS-CoV-2 Nucleocapsid Antibody, Mouse MAb

Order

NUN-S47MouseAnti-SARS-CoV-2 Nucleocapsid Antibody, Mouse MAb

Order

Kits

ACROBiosystems has developed a series of kit products using its high-quality SARS-CoV-2 antigen proteins to improve the efficiency of anti-SARS-CoV-2 drugs and vaccines development. These kit products include SARS-CoV-2 inhibitor screening kits, antibody titer serologic assay kits, antigen detection kit, antigen pre-coated plates and can be used for SARS-CoV-2 inhibitor screening, neutralizing antibody screening, antibody detection, antigen detection.

Inhibitor screening kits
  1. > can screen small molecule inhibitors, polypeptide inhibitors and neutralizing antibodies efficiently and rapidly

  2. > can screen 96 or 480 candidate antibodies simultaneously

Antibody titer assay kits
  1. > High specificity, sensitivity and reproducibility

  2. > can be used in antibody detection, drug screening, vaccine development and other fields

  3. > Different antigen proteins are coated to meet different application requirements

Antigen assay kits
  1. > Double antibody sandwich method was employed in the detection of SARS-COV-2 antigen protein.

  2. > The antigen assay kit with high sensitivity can be used to determine the viral infection status and guide the design of vaccine development.

Antigen pre-coated plates
  1. > High sensitivity, reproducibility and through put

  2. > Suitable for neutralizing antibody screening, biopanning, ELISA assay, etc.

Assay Data

Fig.4 Inhibition of Human ACE2 [Biotinylated]: SARS-CoV-2 S protein RBD Binding by SARS-CoV-2 inhibitor.

Serial dilutions of SARS-CoV-2 inhibitor (Cat. No. AC2-NA005) (1:2 serial dilutions, from 20 μg/mL to 0.039 μg/mL (180 nM to 0.35 nM)) was added into Biotinylated ACE2: SARS-CoV-2 S protein RBD binding reactions. The assay was performed according to the above described protocol. Background was subtracted from data points prior to log transformation and curve fitting.

* Corresponding buffer set offered.(Cat.No. EBS-001 ELISA Buffer Set-96T)

Product list

MoleculeCat. No.SpeciesProduct DescriptionOrder/Preorder
S protein RBDEP-105SARS-CoV-2SARS-CoV-2 Inhibitor Screening Kit

Order

S1 proteinTAS-K001SARS-CoV-2Anti-SARS-CoV-2 Antibody IgG Titer Serologic Assay kit (Spike protein S1)

Order

S protein RBDTAS-K002SARS-CoV-2Anti-SARS-CoV-2 Antibody IgG Titer Serologic Assay kit (Spike protein RBD)

Order

S protein RBDTAS-K003SARS-CoV-2Anti-SARS-CoV-2 Neutralizing Antibody Titer Serologic Assay kit

Order

S proteinTAS-K007SARS-CoV-2Anti-SARS-CoV-2 Antibody IgG Titer Serologic Assay kit (S protein trimer)

Order

Nucleocapsid ProteinTAS-K008SARS-CoV-2Anti-SARS-CoV-2 Antibody IgG Titer Serologic Assay kit (Nucleocapsid Protein)

Order

S1 proteinSP-12SARS-CoV-2SARS-CoV-2 Spike S1 protein-Coated Plates, Clear, 96-Well

Order

S protein RBDRP-13SARS-CoV-2SARS-CoV-2 Spike protein RBD-Coated Plates, Clear, 96-Well

Order

Pre-coupling magnetic beads

ACROBiosystems has developed high-quality S1 protein and RBD protein pre-coupled magnetic beads, which are ready to use and of high stability, high-efficiency target capture and minimal non-specific binding, and can significantly improve the screening efficiency of COVID-19 neutralizing antibody.

Assay Data

Fig.5 Binding of RBD coupled protein to Anti-SARS-CoV-2 S1 antibody:0.1 mg of Beads (1mg/mL, 100 L) was washed for three times and supernatant was removed.

Antibodies of the corresponding concentration of 100 L (10 g/mL~0.039 g/mL) were added. One hour later,fluorescent labeled secondary antibody was added for another one-hour-reaction, the corresponding Binding signal was detected and the Binding curve as obtained.

Product list

MoleculeCat. No.SpeciesProduct DescriptionOrder/Preorder
S1 proteinMBS-K001SARS-CoV-2SARS-CoV-2 Spike S1 protein-coupled magnetic beads

Order

S protein RBDMBS-K002SARS-CoV-2SARS-CoV-2 Spike protein RBD-coupled magnetic beads

Order

More SARS-CoV-2 related products

>>> Proteins for COVID-19 Serological Test Development

>>> SARS-CoV-2 related kit products

>>> Pre-coupling protein magnetic beads

>>> Any custom requests, suggestions or feedback are welcome. click here.

This web search service is supported by Google Inc.

totop