0
There is no goods in the shopping cart !
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 0-9
Your Position: Home > SARS-CoV-2 Related Products

SARS-CoV-2 Related Products

SARS-CoV-2 Proteins and Inhibitor Screening Kit

The pandemic caused by SARS-CoV-2 is a public health emergency of international concern. Data from WHO showed that there were more than 7.38 million confirmed cases globally by June 12, 2020. ACROBiosystems has been keeping a close eye on the development of the epidemic situation and accelerating the development of SARS-COV-2 antigen proteins, antibodies, kits and other related products to facilitate the development of serologic tests,therapeutic antibodies and vaccines.

ACROBiosystems has developed more than 60 products related to SARS-CoV-2, including recombinant proteins, antibodies, kits, beads and so on covering the critical targets of SARS-CoV-2. ACROBiosystems has provided core proteins and antibody materials for several in vitro diagnostic companies to support the development of SARS-COV-2 diagnostic kits.

Antibodies

ACROBiosystems has developed a series of Anti-SARS-CoV-2 antibodies, including the matched antibody pairs with high sensitivity and affinity used for antigen detection of diagnostic kit development. Additionally, we also developed the unique neutralizing antibodies isolated from the convalescent patients' serum.

Matched antibody pairs
  1. Applied in antigen detection method of diagnostics kit development.

  2. > High sensitivity of 12 pg/mL (ELISA assay)

  3. > Super affinity of 0.01 nM level (BLI assay)

  4. > Large scale supply available

Neutralizing antibody
  1. Used as a control for neutralizing antibody titer detection and pseudovirus neutralizing experiment, etc.

  2. > High neutralizing ability and specificity

  3. > Isolated from the convalescent patients' serum

  4. > HEK293 expressed and high batch-to-batch consistency

Human derived antibody
  1. Used as a control for antibody titer detection and western blot, etc.

  2. > High specificity

  3. > Isolated from the convalescent patients' serum

  4. > HEK293 expressed and high batch-to-batch consistency

Assay Data

High sensitivity of 12 pg/mL (ELISA assay)

Fig 1 Immobilized Anti- SARS-CoV-2 Nucleocapsid antibody, mouse Mab (Cat. No. NUN-S46) at 4 μg/mL, add increasing concentrations of SARS-CoV-2 Nucleocapsid protein and then add Biotinylated Anti- SARS-CoV-2 Nucleocapsid antibody, mouse Mab (Cat. No. NUN-S47). Detection was performed using HRP-conjugated streptavidin with sensitivity of 12 pg/mL.

Super affinity of 0.01 nM level(BLI assay)

Fig 2 Anti-SARS-CoV-2 Nucleocapsid Antibody, Mouse MAb(Cat. No. NUN-S47) can bind SARS-CoV-2 Nucleocapsid Protein(Cat. No. NUN-C5227) with an affinity constant of 24.7pM determined in BLI assay (ForteBio Octet Red96e)

Product list

MoleculeCat. No.SpeciesProduct DescriptionOrder/Preorder
Nucleocapsid proteinNUN-S41HumanAnti-SARS-CoV-2 Nucleocapsid Antibody, Human IgG1

Order

NUN-S42HumanAnti-SARS-CoV-2 Nucleocapsid Antibody, Human IgG1

Order

NUN-S46A1MouseAnti-SARS-CoV-2 Nucleocapsid Antibody, Mouse mAb

Order

NUN-S47A1MouseAnti-SARS-CoV-2 Nucleocapsid Antibody, Mouse mAb

Order

S1 proteinS1N-M122MouseAnti-SARS-CoV-2 Spike S1 Antibody, Chimeric mAb

Order

S1N-M130MouseAnti-SARS-CoV-2 Spike S1 Antibody, Chimeric mAb

Order

S1 protein NTDSPD-M121MouseAnti-SARS-CoV-2 Spike NTD antibody, Human IgG1

Order

S protein RBDSAD-S35HumanAnti-SARS-CoV-2 RBD Neutralizing Antibody, Human IgG1

Order

SPD-M141MouseAnti-SARS-CoV-2 Spike RBD Antibody, Human IgM

Order

Recombinant Proteins

SARS-CoV-2 is an enveloped positive-stranded RNA virus that consists of four structural proteins including spike (S) glycoprotein, envelope (E) protein, membrane (M) protein, and nucleocapsid (N) protein. Spike glycoprotein is the most important surface protein of SARS-CoV-2, which can mediate the virus entry into human respiratory epithelial cells by interacting with cell surface receptor angiotensin-converting enzyme 2 (ACE2). S, S1 and S RBD proteins are important targets in the development of SARS-COV-2 therapeutics and vaccines. The quality and application of SARS-COV-2 S, S1, S RBD and human ACE2 and other proteins are the key to the development of antiviral drugs.

ACROBiosystems has developed nearly 50 kinds of high-quality proteins related to SARS-CoV-2 based on HEK293 human cell expression platform. The natural bioactivities and affinities were verified by ELISA/MALS/SPR/BLI, etc.

Antigens for COVID-19 diagnostics
  1. > Customized formulation and bulk order available

  2. > High purity and batch-to-batch consistency

  3. > Validated bioactivity

Trimer S protein
(Exclusive)
  1. > Molecular weight and polymer structure verified by SEC-MALS

  2. > Bioactivity verified

  3. > Biologically function well

Biotinylated proteins
(Featured)
  1. > Unique Avitag™ technology employed

  2. > Uniform labeling, and natural activity

  3. > High purity and batch-to-batch consistency

Antigenic proteins
  1. > Authentic conformation and complete glycosylation

  2. > High purity and batch-to-batch consistency

  3. > Bioactivities verified

Associated host
ACE2 proteins
  1. > High purity and batch-to-batch consistency

  2. > High activity and affinity

  3. > Multiple species

Assay Data

Fig 3. The purity of SARS-CoV-2 S protein (R683A, R685A), His Tag, Super stable trimer (Cat. No. SPN-C52H9) was more than 90% verified by SDS-PAGE under reducing (R) condition. The molecular weight was around 550-660 kDa confirmed by SEC-MALS. The particles are similar in size and appearance to SARS-CoV-2 trimers reported in published literature verified by negative stain electron micrography.

Fig.4 Immobilized Human ACE2, Fc Tag (Cat. No. AC2-H5257) at 2 μg/mL (100 μL/well) can bind SARS-CoV-2 S protein (R683A, R685A), His Tag, Super stable trimer (Cat. No. SPN-C52H9) with a linear range of 0.5-16 ng/mL.



Product list

MoleculeCat. No.SpeciesTagHostProduct DescriptionOrder/Preorder
ACE2AC2-H52H8HumanHis TagHEK293Human ACE2 / ACEH Protein, His Tag (MALS verified)

Order

AC2-H82E6HumanHis Tag & Avi TagHEK293Biotinylated Human ACE2 / ACEH Protein, His,Avitag™ (MALS verified)

Order

AC2-H5257HumanFc TagHEK293Human ACE2 / ACEH Protein, Fc Tag (MALS verified)

Order

AC2-H82F9HumanFc Tag & Avi TagHEK293Biotinylated Human ACE2 / ACEH Protein, Fc,Avitag™

Order

AC2-C52H7CynomolgusHis TagHEK293Cynomolgus ACE2 / ACEH Protein, His Tag

Order

AC2-M5248MouseHis TagHEK293Mouse ACE2 / ACEH Protein, His Tag (MALS verified)

Order

AC2-R5246RatHis TagHEK293Rat ACE2 / ACEH Protein, His Tag (MALS verified)

Order

AC2-P5248Paguma larvataHis TagHEK293Paguma larvata ACE2 / ACEH Protein, His Tag (SPR verified)

Order

S proteinSPN-C52H9SARS-CoV-2His TagHEK293SARS-CoV-2 (COVID-19) S protein (R683A, R685A), His Tag, Super stable trimer (MALS & NS-EM verified)

Order

SPN-C82E9SARS-CoV-2His Tag & Avi TagHEK293Biotinylated SARS-CoV-2 (COVID-19) S protein (R683A, R685A), His,Avitag™, Super stable trimer (MALS verified)

Order

SPN-C52H8SARS-CoV-2His TagHEK293SARS-CoV-2 (COVID-19) S protein (R683A, R685A), His Tag, active trimer (MALS verified)

Order

SPN-S52H5SARSHis TagHEK293SARS S protein (R667A), His Tag

Order

S1 proteinS1N-C52H4SARS-CoV-2His TagHEK293SARS-CoV-2 (COVID-19) S1 protein, His Tag (MALS verified)

Order

S1N-C52H3SARS-CoV-2His TagHEK293SARS-CoV-2 (COVID-19) S1 protein, His Tag

Order

S1N-C5256SARS-CoV-2His TagHEK293SARS-CoV-2 (COVID-19) S1 protein (D614G), His Tag

Order

S1N-C82E3SARS-CoV-2His Tag & Avi TagHEK293Biotinylated SARS-CoV-2 (COVID-19) S1 protein (D614G), His,Avitag™

Order

S1N-C82E8SARS-CoV-2His Tag & Avi TagHEK293Biotinylated SARS-CoV-2 (COVID-19) S1 protein, His,Avitag™ (MALS verified)

Order

S1N-C5255SARS-CoV-2Fc TagHEK293SARS-CoV-2 (COVID-19) S1 protein, Fc Tag

Order

S1N-C5257SARS-CoV-2Mouse IgG Fc TagHEK293SARS-CoV-2 (COVID-19) S1 protein, Mouse IgG2a Fc Tag

Order

S1N-S52H5SARSHis TagHEK293SARS S1 protein, His Tag (MALS verified)

Order

SIN-V52H3HCoV-NL63His TagHEK293HCoV-NL63 S1 protein, His Tag

Order

SIN-V52H4HCoV-229EHis TagHEK293HCoV-229E S1 protein, His Tag

Order

S protein RBDSPD-C52H3SARS-CoV-2His TagHEK293SARS-CoV-2 (COVID-19) S protein RBD, His Tag (MALS verified)

Order

SPD-C82E9SARS-CoV-2His Tag & Avi TagHEK293Biotinylated SARS-CoV-2 (COVID-19) S protein RBD, His,Avitag™ (MALS verified)

Order

SPD-S52H4SARS-CoV-2His TagHEK293SARS-CoV-2 (COVID-19) S protein RBD (V367F), His Tag

Order

SPD-S52H5SARS-CoV-2His TagHEK293SARS-CoV-2 (COVID-19) S protein RBD (N354D), His Tag

Order

SPD-S52H7SARS-CoV-2His TagHEK293SARS-CoV-2 (COVID-19) S protein RBD (W436R), His Tag

Order

SPD-S52H8SARS-CoV-2His TagHEK293SARS-CoV-2 (COVID-19) S protein RBD (R408I), His Tag

Order

SPD-S52H3SARS-CoV-2His TagHEK293SARS-CoV-2 (COVID-19) S protein RBD (N354D, D364Y), His Tag

Order

SPD-C52H4SARS-CoV-2His TagHEK293SARS-CoV-2 (COVID-19) S protein RBD (G476S), His Tag

Order

SPD-C52H5SARS-CoV-2His TagHEK293SARS-CoV-2 (COVID-19) S protein RBD (V483A), His Tag

Order

SPD-C5255SARS-CoV-2Fc TagHEK293SARS-CoV-2 (COVID-19) S protein RBD, Fc Tag (MALS verified)

Order

SPD-C5259SARS-CoV-2Mouse IgG Fc TagHEK293SARS-CoV-2 (COVID-19) S protein RBD, Mouse IgG2a Fc Tag(MALS verified)

Order

SPD-C82AaSARS-CoV-2Mouse IgG Fc Tag & Avi TagHEK293Biotinylated SARS-CoV-2 (COVID-19) S protein RBD, Mouse IgG1 Fc,Avitag™(MALS verified)

Order

SPD-S52H6SARSHis TagHEK293SARS S protein RBD, His Tag (MALS verified)

Order

S1 protein NTDS1D-C52H6SARS-CoV-2His TagHEK293SARS-CoV-2 (COVID-19) S1 protein NTD, His Tag

Order

S1 protein CTDS1D-C52H3SARS-CoV-2His TagHEK293SARS-CoV-2 (COVID-19) S1 protein CTD, His Tag (MALS-verified)

Order

S2 proteinS2N-C52H5SARS-CoV-2His TagHEK293SARS-CoV-2 (COVID-19) S2 protein, His Tag

Order

Nucleocapsid proteinNUN-C5227SARS-CoV-2His TagHEK293SARS-CoV-2 (COVID-19) Nucleocapsid protein, His Tag

Order

NUN-C51H9SARS-CoV-2His TagE.coliSARS-CoV-2 (COVID-19) Nucleocapsid protein, His Tag

Order

NUN-C81Q6SARS-CoV-2His Tag & Avi TagE.coliBiotinylated SARS-CoV-2 (COVID-19) Nucleocapsid protein, His,Avitag™

Order

NUN-S5229SARSHis TagHEK293SARS Nucleocapsid protein, His Tag

Order

Envelope proteinENN-C5128SARS-CoV-2His Tag & GST TagE.coliSARS-CoV-2 (COVID-19) Envelope protein, GST,His Tag

Order

Papain-like ProteasePAE-C5148SARS-CoV-2His TagE.coliSARS-CoV-2 (COVID-19) Papain-like Protease Protein, His Tag

Order

RNA-dependent RNA polymeraseRNE-C55HaSARS-CoV-2His TagInsectCellsSARS-CoV-2 (COVID-19) RNA-dependent RNA polymerase Protein, His Tag

Order

NSP1NS1-C51H7SARS-CoV-2His TagE.coliSARS-CoV-2 (COVID-19) NSP1 Protein, His Tag

Order

NSP7NS7-C51H6SARS-CoV-2His TagE.coliSARS-CoV-2 (COVID-19) NSP7 Protein, His Tag (MALS verified)

Order

NSP8NS8-C5149SARS-CoV-2His TagE.coliSARS-CoV-2 (COVID-19) NSP8 Protein, His Tag

Order

NSP7 & NSP8NS8-C5125SARS-CoV-2His TagE.coliSARS-CoV-2 (COVID-19) NSP7&NSP8 Protein, His Tag

Order

NSP16 & NSP10NS0-C51W3SARS-CoV-2His Tag & Strep TagE.coliSARS-CoV-2 (COVID-19) NSP16&NSP10 Heterodimer Protein, His Tag&Twin Strep Tag

Order

S protein RBDSPD-M52H6MERSHis TagHEK293MERS S protein RBD, His Tag

Preorder

S1 proteinSIN-V52H5HCoV-OC43His TagHEK293HCoV-OC43 S1 protein, His Tag

Preorder

SIN-V52H6HCoV-HKU1(isolate N5)His TagHEK293HCoV-HKU1(isolate N5) S1 protein, His Tag

Preorder

Nucleocapsid proteinNUN-V52H3HCoV-OC43His TagHEK293HCoV-OC43 Nucleocapsid protein, His Tag

Preorder

NUN-V52H4HCoV-HKU1(isolate N5)His TagHEK293HCoV-HKU1(isolate N5) Nucleocapsid protein, His Tag

Preorder

NUN-V52H6HCoV-NL63His TagHEK293HCoV-NL63 Nucleocapsid protein, His Tag

Preorder

NUN-V52H8HCoV-229EHis TagHEK293HCoV-229E Nucleocapsid protein, His Tag

Preorder

NUN-M52H5MERSHis TagHEK293MERS Nucleocapsid protein, His Tag

Preorder

Kits

ACROBiosystems has developed a series of kit products using its high-quality SARS-CoV-2 antigen proteins to improve the efficiency of anti-SARS-CoV-2 drugs and vaccines development. These kit products include SARS-CoV-2 inhibitor screening kits, antibody titer serologic assay kits, antigen detection kit, antigen pre-coated plates and can be used for SARS-CoV-2 inhibitor screening, neutralizing antibody screening, antibody detection, antigen detection.

Inhibitor screening kits
  1. > can screen small molecule inhibitors, polypeptide inhibitors and neutralizing antibodies efficiently and rapidly

  2. > can screen 96 or 480 candidate antibodies simultaneously

Antibody titer assay kits
  1. > High specificity, sensitivity and reproducibility

  2. > can be used in antibody detection, drug screening, vaccine development and other fields

  3. > Different antigen proteins are coated to meet different application requirements

Antigen assay kits
  1. > Double antibody sandwich method was employed in the detection of SARS-COV-2 antigen protein.

  2. > The antigen assay kit with high sensitivity can be used to determine the viral infection status and guide the design of vaccine development.

Antigen pre-coated plates
  1. > High sensitivity, reproducibility and through put

  2. > Suitable for neutralizing antibody screening, biopanning, ELISA assay, etc.

Assay Data

Fig.5 Inhibition of Human ACE2 [Biotinylated]: SARS-CoV-2 S protein RBD Binding by SARS-CoV-2 inhibitor.

Serial dilutions of SARS-CoV-2 inhibitor (Cat. No. AC2-NA005) (1:2 serial dilutions, from 20 μg/mL to 0.039 μg/mL (180 nM to 0.35 nM)) was added into Biotinylated ACE2: SARS-CoV-2 S protein RBD binding reactions. The assay was performed according to the above described protocol. Background was subtracted from data points prior to log transformation and curve fitting.

* Corresponding buffer set offered.(Cat.No. EBS-001 ELISA Buffer Set-96T)

Product list

MoleculeCat. No.SpeciesProduct DescriptionOrder/Preorder
S protein RBDEP-105SARS-CoV-2SARS-CoV-2 Inhibitor Screening Kit

Order

S1 proteinTAS-K001SARS-CoV-2Anti-SARS-CoV-2 Antibody IgG Titer Serologic Assay kit (Spike protein S1)

Order

S protein RBDTAS-K002SARS-CoV-2Anti-SARS-CoV-2 Antibody IgG Titer Serologic Assay kit (Spike protein RBD)

Order

S protein RBDTAS-K003SARS-CoV-2Anti-SARS-CoV-2 Neutralizing Antibody Titer Serologic Assay kit

Order

S proteinTAS-K007SARS-CoV-2Anti-SARS-CoV-2 Antibody IgG Titer Serologic Assay kit (S protein trimer)

Order

Nucleocapsid ProteinTAS-K008SARS-CoV-2Anti-SARS-CoV-2 Antibody IgG Titer Serologic Assay kit (Nucleocapsid Protein)

Order

S protein RBDTAS-K009SARS-CoV-2Total of Anti-SARS-CoV-2 Antibody Titer Serologic Assay kit

Order

Nucleocapsid ProteinTAS-K010SARS-CoV-2SARS-CoV-2 Nucleocapsid Protein Titer Assay Kit

Order

S proteinTAS-K011SARS-CoV-2SARS-CoV-2 Spike Protein Titer Assay Kit

Order

S1 proteinTAS-K012SARS-CoV-2Anti-SARS-CoV-2 Antibody IgM Serologic Assay kit (S1 protein)

Order

S protein RBDTAS-K013SARS-CoV-2Anti-SARS-CoV-2 Antibody IgM Serologic Assay kit (Spike RBD protein)

Order

S1 proteinSP-12SARS-CoV-2SARS-CoV-2 Spike S1 protein-Coated Plates, Clear, 96-Well

Order

S protein RBDRP-13SARS-CoV-2SARS-CoV-2 Spike protein RBD-Coated Plates, Clear, 96-Well

Order

Pre-coupling magnetic beads

ACROBiosystems has developed high-quality S1 protein and RBD protein pre-coupled magnetic beads, which are ready to use and of high stability, high-efficiency target capture and minimal non-specific binding, and can significantly improve the screening efficiency of COVID-19 neutralizing antibody.

Assay Data

Fig.6 Binding of RBD coupled protein to Anti-SARS-CoV-2 S1 antibody:0.1 mg of Beads (1mg/mL, 100 L) was washed for three times and supernatant was removed.

Antibodies of the corresponding concentration of 100 L (10 g/mL~0.039 g/mL) were added. One hour later,fluorescent labeled secondary antibody was added for another one-hour-reaction, the corresponding Binding signal was detected and the Binding curve as obtained.

Product list

MoleculeCat. No.SpeciesProduct DescriptionOrder/Preorder
S1 proteinMBS-K001SARS-CoV-2SARS-CoV-2 Spike S1 protein-coupled magnetic beads

Order

S protein RBDMBS-K002SARS-CoV-2SARS-CoV-2 Spike protein RBD-coupled magnetic beads

Order

ACE2MBS-K013SARS-CoV-2Human ACE2-coupled magnetic beads

Order

S protein RBDMBS-K014SARS-CoV-2Anti-SARS-CoV-2 Spike RBD Antibody-coupled magnetic beads

Order

More SARS-CoV-2 related products

>>> Proteins for COVID-19 Serological Test Development

>>> SARS-CoV-2 related kit products

>>> Pre-coupling protein magnetic beads

>>> Any custom requests, suggestions or feedback are welcome. click here.

This web search service is supported by Google Inc.

totop