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Enzymes

Target enzyme
Target enzyme
Tool enzyme
Tool enzyme
mRNA enzyme
mRNA enzyme
Target enzyme

Enzymes are catalysts in organisms that regulate chemical reactions without undergoing changes themselves. They are important biological targets for drug development, offering unique opportunities for drug design. Enzyme inhibitors play a crucial role in developing oral therapeutic agents used in clinical practice.

ACROBiosystems offers a range of target enzyme products for drug development. These include targets in adenosinergic pathways, matrix metalloproteinases, lysosomal proteases, and kinases. These products support the development of drugs and therapies targeting these enzymes.

                Target enzyme
Product Features
Proteins with multiple species, including human, mouse, cynomolgus, rabbit, and canine, are suitable for cross-species experiments.
Verified high purity: more than 95% as verified by SDS-PAGE; more than 90% as verified by SEC-MALS.
Enhanced enzymatic activity for improved substrate catalysis and drug screening.
Reliable and reproducible results with consistent batch-to-batch performance.
Featured products
The critical targets for adenosinergic pathways
The critical targets for adenosinergic pathways
KRAS proteases
KRAS proteases
Cathepsin B proteases
Cathepsin B proteases
> The critical enzyme for adenosinergic pathways (Click molecular to learn more details)
> Protease
> Kinase
> Alkaline phosphatase-like enzyme
> Others
TransglutaminasesProtein Arginine DeiminasePADI2PADI3PADI6
Ubiquitin Related ProteinsCBLBElongin B & Elongin C & VHLUBE1UCH-L1UCH-L3RNF43
OxidoreductasesIDH1TDO2Xanthine dehydrogenase
HydrolasesAngiogeninbeta-Galactosidase-1beta-Glucuronidase/GUSBGlucosylceramidaseMatriptasePH20Plasma Kallikrein/KLKB1Prostatic Acid Phosphatase
PhosphatasePTPRD
Carbonic AnhydraseCarbonic Anhydrase IICarbonic Anhydrase IXCarbonic Anhydrase XII
OthersPlexin B1Plexin B2GAS6
Applications
High purity verified by SEC-MALS
CD73蛋白高纯度经MALS验证
The purity of Cynomolgus CD39, His Tag (Cat. No. CD9-C52H3) is more than 95% and the molecular weight of this protein is around 62-84 kDa verified by SEC-MALS.
Enzyme activity data
ProductHuman Cathepsin B proteases / CTSB Protein, His Tag (active enzyme)(Cat.No. CTB-H5222)
SubstrateFluorogenic peptide substrate Z-LR-AMC
Enzyme Activity
(pmol/min/μg)
> 2500
ProductHuman KRAS (2-185,G12C) Protein, His Tag (active enzyme)(Cat.No. KRS-H51H3)
SubstrateGTPase-Glo test kras activity
Enzyme ActivityGTP≤85%
Tool enzyme

Tool enzymes, including nucleic acid enzymes, have diverse functions like restriction, polymerization, ligation, modification, and cleavage. They efficiently recognize specific sequences and enable the manipulation and analysis of nucleic acids. These enzymes are widely used to detect and study biologically active molecules.

ACROBiosystems offers CAS nucleases, including universal nucleases, CAS9, and CAS12a, for cell and gene engineering, as well as regulatory safety monitoring of biological products.

ACROBiosystems also provides tool enzymes for antibody analysis, aiding in antibody fragmentation, glycosylation analysis, and exploring the relationship between antibody structure and function. These tools contribute to the development and quality control of biopharmaceuticals.

Tool enzyme
Product Features
High Purity, as determined by SDS-PAGE (>90%) and SEC-MALS
Verified high enzymatic activity
Animal component-free
Featured products
GENIUS™ Nuclease
GENIUS™ Nuclease
Cas Enzyme
Cas Enzyme
Enzymes for Antibody Characterization
Enzymes fo Antibody Characterization
> Nuclease
TypeMolecularCat. No.Description
GENIUS™ NucleaseNuclease HOTBEE-N3116GENIUS™Nuclease DMF Filed
Nuclease HOTNUE-S5119GENIUS™ Nuclease, premium grade
Nuclease HOTGMP-NUES19GMP GENIUS™Nuclease DMF Filed
Cas Enzymecas9CA9-S5149GENPower™ NLS-Cas9 Nuclease (MALS verified)
Cas12aCAA-L5140GENPower™ NLS-Cas12a Nuclease (MALS verified)
Cas12aCAA-L5149NLS-Cas12a Nuclease (MALS verified)
> Protease
TypeMolecularCat. No.DescriptionApplication
Protease3C(HRV)3CC-N3133HRV-3C Protease Cleavage Enzyme, GST Tag (active enzyme)HRV-3C removes affinity tag from fusion protein.
Enzymes for Antibody CharacterizationIdeSIDS-S5143IdeS (20U/μl)IdeS specifically cleaves IgGs below the hinge region into F(ab´)2 and Fc fragments.
SpeBSPB-S5115SpeB (40U/μl)SpeB digests IgG to generate Fab and Fc fragments.
Endo HENH-S5116Endo H (500U/μl)Endo H cleaves asparagine-linked (N-linked) hybrid or high mannose oligosaccharides but not complex oligosaccharides.
EndoSENS-S5143Endo S (200U/μl)EndoS preferentially cleaves complex oligosaccharides and does not cleave asparagine-linked (N-linked) hybrid or high mannose oligosaccharides.
Applications
The high enzyme activity is verified by in-vitro experiments
NLS-Cas12a Nuclease (MALS verified) (Cat. No. CAA-L5149)substrate cutting efficiency>90%,the cleavage activity is comparable to that of competing products
NLS-Cas12a Nuclease (MALS verified)
Measured by its ability to cleave a targeted DNA substrate. Cas12a achieves >90% substrate cleavage, comparable to competing products
High bioactivity
GENIUS™ Nuclease, premium grade
GENIUS™ Nuclease, premium grade(Cat. No. NUE-S5119)shows higher specific activity than other competitors.
High batch consistency
GENIUS™ Nuclease, premium grade
GENIUS™ Nuclease, premium grade
GENIUS™ Nuclease, premium grade (Cat. No. NUE-S5119), exhibits consistent bioactivity across different batches, ensuring high inter-batch uniformity.
mRNA enzyme

During mRNA synthesis, modifications are employed to enhance translation efficiency, stability, and prevent degradation. These modifications involve capping the 5' end and appending a poly(A) tail at the 3' end of mRNA. ACROBiosystems offers enzyme products that facilitate mRNA synthesis and modification. These enzymes are of high purity, possess activity, and are free from contaminants. They effectively tackle challenges associated with capping efficiency, poly(A) tail sequences, mRNA stability, and cell delivery.

mRNA enzyme
Product Features
Verified high purity
Verified high activity
Low endotoxin
Low dsRNA contamination
Product list
MolecularCat. No.Description
T7 RNA PolymeraseT7E-E5143T7 RNA Polymerase(50U/μl)
PyrophosphatasePYE-T5143Thermostable Inorganic Pyrophosphatase (2 U/μl)
PyrophosphatasePYE-S5143Pyrophosphatase, Inorganic (yeast) (0.1 U/μl)
Rnase InhibitorRNR-M5143Murine RNase Inhibitor (40 U/μl)
DNase IDNI-B52H3DNase I(50U/μl)
Poly(A) PolymerasePOE-E5143E. coli Poly(A) Polymerase (5U/ul)
RNase RRNR-E5146RNase R (20 U/μl)
Ribonuclease 3RI3-E5143RNase Ⅲ (2U/μl)

>  Learn more about ComboX, a combination of universal solutions

ComboX, a combination of universal solutions
ACRO Quality

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