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PE-CY7-Labeled Monoclonal Anti-Human CD3 Antibody, Mouse IgG2a (OKT3) (0.03% Proclin)

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FABm001-04-200tests (50tests X 4)
$200.00
ETA of in-stock products:2 business days
Sub-Total$ 0
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Product Details

  • Source

    Monoclonal Anti-Human CD3 Antibody, Mouse IgG2a (Clone: OKT3) is a monoclonal antibody recombinantly expressed from human 293 cells (HEK293), which provides higher batch consistency and long term security of supply.

  • Antibody Type

    Recombinant Monoclonal

  • Clone

    OKT3

  • Isotype

    Mouse IgG2a, Kappa

  • Host Species

    Mouse

  • Reactivity

    Human

  • Immunogen

    Purified Human CD3 epsilon Protein

  • Conjugate

    PE-CY7

    Excitation Wavelength: 561 nm

    Emission Wavelength: 780 nm

  • Specificity

    This product is a specific antibody specifically reacts with CD3 epsilon protein.

  • Recommended Dilution

    1:20

  • Form

    Liquid

  • Formulation

    Supplied as 0.2 μm-filtered solution in PBS (pH 7.4) containing 0.03% ProClin 300 and 0.2% BSA, with trehalose as protectant.

    Please contact us for customized product forms or formulations.

  • Shipping

    Liquid product is shipped at blue ice.

  • Storage

    Please protect from light and avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. Store at 2-8 °C for 12 months.

  • Notices

    Product Specific Notices: For research use only.

  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • Bioactivity-FACS

    CD3 FACS

    Flow cytometric analysis of Jurkat staining with PE-CY7-Labeled Monoclonal Anti-Human CD3 Antibody, Mouse IgG2a (OKT3) (Cat. No. FABm001-04) at 1:20 dilution (5 μL of the antibody stock solution corresponds to labeling of 1e6 cells in a final volume of 100 µL), compared with isotype control antibody. PE-CY7 signal was used to evaluate the binding activity (QC tested).

    Protocol

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Background

CD3e molecule, epsilon is also known as CD3E, is a T-cell surface single-pass type I membrane glycoprotein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. CD3E plays an essential role in T-cell development, and defects in CD3E gene cause severe immunodeficiency. CD3E gene has also been linked to a susceptibility to type I diabetes in women. CD3E has been shown to interact with TOP2B, CD3EAP and NCK2.

Recent Advances

 
Drug Development Progress
  • English Name：

    T cell surface glycoprotein CD3

  • Category：

  • Approved Drugs：

    10 Details

  • Drugs in Clinical Trials：

    198 Details

  • Highest Development Stage：

    Approved

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