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APC-CY7-Labeled Monoclonal Anti-Human CD8 Antibody, Mouse IgG1

COADS MS
DS

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Cat. No. / Size
Price
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FABm003-05-200tests (50tests X 4)
$560.00
ETA of in-stock products:2 business days
Sub-Total$ 0
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Product Details

  • Isotype

    Mouse IgG1, Kappa

  • Host Species

    Mouse

  • Reactivity

    Human

  • Conjugate

    APC-CY7

    Excitation Wavelength: 637 nm

    Emission Wavelength: 780 nm

  • Specificity

    This product is a specific antibody specifically reacts with CD8 protein.

  • Application

    This APC-CY7-CD8 Antibody is specifically developed for flow cytometry applications to detect the expression of CD8 on human cells. Additionally, the Human TBNK 6-color Cocktail Flow Panel kit (Cat. No. ICA-A001) is available, with the APC-CY7-CD8 Antibody being one component of the kit.

  • Recommended Dilution

    1:20

  • Form

    Liquid

  • Formulation

    Supplied as 0.2 μm-filtered solution in PBS (pH 7.4) containing 0.03% ProClin 300 and 0.2% BSA, with trehalose as protectant.

    Please contact us for customized product forms or formulations.

  • Shipping

    Liquid product is shipped at blue ice.

  • Storage

    Please protect from light and avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. Store at 2-8 °C for 12 months.

  • Notices

    Product Specific Notices: For research use only.

  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • Bioactivity-FACS

    CD8 FACS

    Flow cytometric analysis of Human peripheral blood lymphocytes respectively staining with APC-CY7-Labeled Monoclonal Anti-Human CD8 Antibody Mouse IgG1 (Cat. No. FABm003-05) at 1:20 dilution (5 μL of the antibody stock solution corresponds to labeling of 2.5e5 cells in a final volume of 100 µL), compared with isotype control antibody. APC-CY7 signal was used to evaluate the binding activity (QC tested).

    Protocol

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Background

CD8a is a 32-34 kD type I glycoprotein. It forms a homodimer (CD8a/a) or heterodimer (CD8a/b) with CD8b. CD8, also known as T8 and Leu2, is a member of the immunoglobulin superfamily found on the majority of thymocytes, a subset of peripheral blood T cells, and NK cells (which express almost exclusively CD8a homodimers). CD8 acts as a co-receptor with MHC class I-restricted T cell receptors in antigen recognition and T cell activation and has been shown to play a role in thymic differentiation. Two domains in CD8a are important for function: the extracellular IgSF domain binds the α3 domain of MHC class I and the cytoplasmic CXCP motif binds the tyrosine kinase p56 Lck.

Recent Advances

 
Drug Development Progress
  • English Name：

    Cluster of differentiation 8

  • Category：

  • Approved Drugs：

    0 Details

  • Drugs in Clinical Trials：

    18 Details

  • Highest Development Stage：

    Phase 3 Clinical

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